論文 - 詳細
| RRC ID | 30940 |
|---|---|
| 著者 | Nargund AM, Pellegrino MW, Fiorese CJ, Baker BM, Haynes CM. |
| タイトル | Mitochondrial import efficiency of ATFS-1 regulates mitochondrial UPR activation. |
| ジャーナル | Science |
| Abstract |
To better understand the response to mitochondrial dysfunction, we examined the mechanism by which ATFS-1 (activating transcription factor associated with stress-1) senses mitochondrial stress and communicates with the nucleus during the mitochondrial unfolded protein response (UPR(mt)) in Caenorhabditis elegans. We found that the key point of regulation is the mitochondrial import efficiency of ATFS-1. In addition to a nuclear localization sequence, ATFS-1 has an N-terminal mitochondrial targeting sequence that is essential for UPR(mt) repression. Normally, ATFS-1 is imported into mitochondria and degraded. However, during mitochondrial stress, we found that import efficiency was reduced, allowing a percentage of ATFS-1 to accumulate in the cytosol and traffic to the nucleus. Our results show that cells monitor mitochondrial import efficiency via ATFS-1 to coordinate the level of mitochondrial dysfunction with the protective transcriptional response. |
| 巻・号 | 337(6094) |
| ページ | 587-90 |
| 公開日 | 2012-8-3 |
| DOI | 10.1126/science.1223560 |
| PII | science.1223560 |
| PMID | 22700657 |
| PMC | PMC3518298 |
| MeSH | Active Transport, Cell Nucleus Animals Caenorhabditis elegans / genetics Caenorhabditis elegans / metabolism* Caenorhabditis elegans Proteins / genetics Caenorhabditis elegans Proteins / metabolism* Cell Nucleus / metabolism* Gene Expression Regulation Mitochondria / metabolism* Nuclear Localization Signals / genetics Nuclear Localization Signals / metabolism Stress, Physiological* Transcription Factors / genetics Transcription Factors / metabolism* Transcription, Genetic Unfolded Protein Response* |
| IF | 41.846 |
| 引用数 | 390 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 50 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | atfs-1(tm4525)V |