| RRC ID |
31030
|
| Author |
Gospodaryov DV, Lushchak OV, Rovenko BM, Perkhulyn NV, Gerards M, Tuomela T, Jacobs HT.
|
| Title |
Ciona intestinalis NADH dehydrogenase NDX confers stress-resistance and extended lifespan on Drosophila.
|
| Journal |
Biochim Biophys Acta
|
| Abstract |
An assembled cDNA coding for the putative single-subunit NADH dehydrogenase (NDX) of Ciona intestinalis was introduced into Drosophila melanogaster. The encoded protein was found to localize to mitochondria and to confer rotenone-insensitive substrate oxidation in organello. Transgenic flies exhibited increased resistance to menadione, starvation and temperature stress, and manifested a sex and diet-dependent increase in mean lifespan of 20-50%. However, NDX was able only weakly to complement the phenotypes produced by the knockdown of complex I subunits.
|
| Volume |
1837(11)
|
| Pages |
1861-1869
|
| Published |
2014-11-1
|
| DOI |
10.1016/j.bbabio.2014.08.001
|
| PII |
S0005-2728(14)00561-1
|
| PMID |
25124484
|
| IF |
3.411
|
| Times Cited |
11
|
|
WOS Category
|
BIOPHYSICS
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| DNA material |
|
| C.intestinalis / (O.japonicus) |
Ciona intestinalis EST Clones
cibd016c12
ciad062k07
ciem809l11 |
