Reference - Detail
| RRC ID | 31030 |
|---|---|
| Author | Gospodaryov DV, Lushchak OV, Rovenko BM, Perkhulyn NV, Gerards M, Tuomela T, Jacobs HT. |
| Title | Ciona intestinalis NADH dehydrogenase NDX confers stress-resistance and extended lifespan on Drosophila. |
| Journal | Biochim Biophys Acta |
| Abstract |
An assembled cDNA coding for the putative single-subunit NADH dehydrogenase (NDX) of Ciona intestinalis was introduced into Drosophila melanogaster. The encoded protein was found to localize to mitochondria and to confer rotenone-insensitive substrate oxidation in organello. Transgenic flies exhibited increased resistance to menadione, starvation and temperature stress, and manifested a sex and diet-dependent increase in mean lifespan of 20-50%. However, NDX was able only weakly to complement the phenotypes produced by the knockdown of complex I subunits. |
| Volume | 1837(11) |
| Pages | 1861-1869 |
| Published | 2014-11-1 |
| DOI | 10.1016/j.bbabio.2014.08.001 |
| PII | S0005-2728(14)00561-1 |
| PMID | 25124484 |
| IF | 3.411 |
| Times Cited | 11 |
| WOS Category | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| Total number of mentions | 0 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| DNA material | |
| C.intestinalis / (O.japonicus) | Ciona intestinalis EST Clones cibd016c12 ciad062k07 ciem809l11 |