Reference - Detail
| RRC ID | 3141 |
|---|---|
| Author | Hanafy A, Uno J, Mitani H, Kang Y, Mikami Y. |
| Title | In-vitro antifungal activities of sulfa drugs against clinical isolates of Aspergillus and Cryptococcus species. |
| Journal | Nihon Ishinkin Gakkai Zasshi |
| Abstract |
In vitro susceptibilities of ten clinical isolates, including five strains of Cryptococcus neoformans var. grubii and five strains of Aspergillus fumigatus, were determined against nine sulfa drugs using a microdilution method. Among the five tested media, minimum inhibitory concentration (MIC) values were observed only in YNB medium: no detectable level MIC value of less than 125 microg/ml was observed in the four remaining media against Cryptococcus species. Of the nine sulfa drugs, of which sulfaphenazole showed the highest antifungal activity, the MIC values for A. fumigatus and C. neoformans var. grubii were, respectively, 64 microg/ml and 4-8 microg/ml, suggesting high susceptibility of C. neoformans to sulfa drugs. |
| Volume | 48(1) |
| Pages | 47-50 |
| Published | 2007-1-1 |
| DOI | 10.3314/jjmm.48.47 |
| PMID | 17287722 |
| MeSH | Anti-Infective Agents / pharmacology* Aspergillus fumigatus / drug effects* Cryptococcus neoformans / drug effects* Drug Resistance, Fungal Microbial Sensitivity Tests / methods Sulfamethoxazole / pharmacology Sulfaphenazole / pharmacology Sulfur Compounds / pharmacology* |
| Resource | |
| Pathogenic microorganisms | IFM 5817 IFM 5880 IFM 5882 IFM 40215 IFM 40216 IFM 41362 IFM 46089 IFM 46139 IFM 46501 IFM 46660 IFM 47450 IFM 48051 IFM 49624 IFM 49722 IFM 51126 IFM 51976 IFM 53412 IFM 4650 |