| RRC ID |
3163
|
| Author |
Ohshita K, Ishiyama H, Takahashi Y, Ito J, Mikami Y, Kobayashi J.
|
| Title |
Synthesis of penaresidin derivatives and its biological activity.
|
| Journal |
Bioorg Med Chem
|
| Abstract |
A series of stereoisomers for the azetidine ring of penaresidin B was synthesized and their cytotoxic and antimicrobial activities were evaluated. Among six synthetic isomers 1-6, isomers 4 and 5 showed relatively potent cytotoxic activity against A549 (lung) and HT29 (colon) tumor cells as well as antibacterial activity.
|
| Volume |
15(14)
|
| Pages |
4910-6
|
| Published |
2007-7-15
|
| DOI |
10.1016/j.bmc.2007.04.049
|
| PII |
S0968-0896(07)00376-8
|
| PMID |
17509887
|
| MeSH |
Alkanes / chemical synthesis
Alkanes / chemistry*
Alkanes / pharmacology*
Anti-Bacterial Agents / chemical synthesis
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Cell Line, Tumor
Cell Survival / drug effects
Heterocyclic Compounds, 1-Ring / chemical synthesis
Heterocyclic Compounds, 1-Ring / chemistry*
Heterocyclic Compounds, 1-Ring / pharmacology*
Humans
Isomerism
Molecular Structure
Organic Chemicals / chemical synthesis
Organic Chemicals / chemistry*
Organic Chemicals / pharmacology*
Structure-Activity Relationship
|
| IF |
3.073
|
| Times Cited |
29
|
|
WOS Category
|
CHEMISTRY, ORGANIC
CHEMISTRY, MEDICINAL
BIOCHEMISTRY & MOLECULAR BIOLOGY
|
| Resource |
| Pathogenic microorganisms |
IFM 5368
IFM 40213
IFM 46914 |
