Reference - Detail
| RRC ID | 31703 |
|---|---|
| Author | Chen CJ, Chin JE, Ueda K, Clark DP, Pastan I, Gottesman MM, Roninson IB. |
| Title | Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. |
| Journal | Cell |
| Abstract |
Resistance of tumor cells to multiple cytotoxic drugs is a major impediment to cancer chemotherapy. Multidrug resistance in human cells is determined by the mdr1 gene, encoding a high molecular weight membrane glycoprotein (P-glycoprotein). Complete primary structure of human P-glycoprotein has been determined from the cDNA sequence. The protein, 1280 amino acids long, consists of two homologous parts of approximately equal length. Each half of the protein includes a hydrophobic region with six predicted transmembrane segments and a hydrophilic region. The hydrophilic regions share homology with peripheral membrane components of bacterial active transport systems and include potential nucleotide-binding sites. These results are consistent with a function for P-glycoprotein as an energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. |
| Volume | 47(3) |
| Pages | 381-9 |
| Published | 1986-11-7 |
| DOI | 10.1016/0092-8674(86)90595-7 |
| PII | 0092-8674(86)90595-7 |
| PMID | 2876781 |
| MeSH | ATP Binding Cassette Transporter, Subfamily B, Member 1 Amino Acid Sequence Bacterial Proteins / analysis Bacterial Proteins / genetics* Base Sequence Biological Transport, Active Cell Line DNA / analysis Drug Resistance / genetics* Glycoproteins / analysis Glycoproteins / genetics* Humans Molecular Weight Neoplasms / drug therapy Protein Conformation |
| IF | 38.637 |
| Times Cited | 1861 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | Patent(IFI CLAIMS) |
| Total number of mentions | 95 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| DNA material | Human MDR1 cDNA (RDB01372) |