| RRC ID |
31715
|
| Author |
Burger E, Vaz CC, Sano A, Calich VL, Singer-Vermes LM, Xidieh CF, Kashino SS, Nishimura K, Miyaji M.
|
| Title |
Paracoccidioides brasiliensis infection in nude mice: studies with isolates differing in virulence and definition of their T cell-dependent and T cell-independent components.
|
| Journal |
Am J Trop Med Hyg
|
| Abstract |
Athymic and euthymic BALB/c mice infected with highly (Pb18) or slightly (Pb265) virulent Paracoccidioides brasiliensis isolates were compared regarding mortality, presence of viable yeasts, specific immunoglobulin M (IgM) and IgG titers, and the antigen recognition patterns of these antibodies. Isolate Pb18 caused a more severe disease in athymic mice, as supported by higher number of infected organs and shorter survival times. These animals, however, were resistant to Pb265 infection. High titers of antibodies were found only in euthymic mice, seven weeks after Pb18 infection. At this time, euthymic animals presented IgG antibodies to numerous protein bands that were not detected at four weeks postinfection or after Pb265 inoculation. In contrast, antibodies from athymic mice always reacted with few antigen bands. Although the majority of P. brasiliensis antigens are T cell-dependent, the immunodominant gp43 and also the 41.5- and 27.5-kD antigens are here, for the first time, characterized as T cell-independent antigens of P. brasiliensis.
|
| Volume |
55(4)
|
| Pages |
391-8
|
| Published |
1996-10-1
|
| DOI |
10.4269/ajtmh.1996.55.391
|
| PMID |
8916794
|
| MeSH |
Animals
Antibodies, Fungal / blood
Antibodies, Fungal / immunology
Antibody Specificity
Antigens, Fungal / immunology
Immunity, Cellular
Immunoblotting
Immunoglobulin G / blood
Immunoglobulin G / immunology
Immunoglobulin M / blood
Immunoglobulin M / immunology
Male
Mice
Mice, Inbred BALB C
Mice, Nude
Paracoccidioides / immunology
Paracoccidioides / pathogenicity*
Paracoccidioidomycosis / immunology*
Paracoccidioidomycosis / microbiology*
Paracoccidioidomycosis / mortality
Specific Pathogen-Free Organisms
T-Lymphocytes / physiology*
Virulence
Viscera / microbiology
|
| IF |
2.126
|
| Times Cited |
20
|
|
WOS Category
|
TROPICAL MEDICINE
PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
|
| Resource |
| Pathogenic microorganisms |
IFM 41621
IFM 41629
IFM 46466 |
