| RRC ID |
3172
|
| 著者 |
Toyotome T, Adachi Y, Watanabe A, Ochiai E, Ohno N, Kamei K.
|
| タイトル |
Activator protein 1 is triggered by Aspergillus fumigatus beta-glucans surface-exposed during specific growth stages.
|
| ジャーナル |
Microb Pathog
|
| Abstract |
Aspergillus fumigatus has been shown to trigger the activation of nuclear factor-kappaB (NF-kappaB), but it remains unclear whether other transcription factors are also induced following infection by this organism. In this study, we demonstrated that A. fumigatus also triggers activator protein 1 (AP-1), a transcription factor that plays an important role during the production of cytokines and chemokines. Swollen conidia strongly induce the activation of AP-1, and more than 80% of these were stained positively with anti-beta-glucan antibodies by fluorescence microscopy. Hyphae were also stained with anti-beta-glucan antibodies, albeit significantly weaker compared with swollen conidia. Furthermore, our present findings also showed that A. fumigatus triggers the activation of AP-1 in a dectin-1 (receptor for beta-glucan)-dependent manner. These data thus suggest that AP-1 is triggered by beta-glucan recognition on the surface of A. fumigatus. We also showed that Syk tyrosine kinase is required for AP-1 induction in this pathway. We therefore speculate that the dectin-1/Syk/AP-1 signaling pathway plays an important role in the host defense response to fungal infection.
|
| 巻・号 |
44(2)
|
| ページ |
141-50
|
| 公開日 |
2008-2-1
|
| DOI |
10.1016/j.micpath.2007.08.015
|
| PII |
S0882-4010(07)00113-1
|
| PMID |
17928189
|
| MeSH |
Antibodies, Fungal / immunology
Artificial Gene Fusion
Aspergillus fumigatus / immunology*
Genes, Reporter
Hyphae / immunology
Intracellular Signaling Peptides and Proteins / immunology
Lectins, C-Type
Luciferases / genetics
Luciferases / metabolism
Membrane Proteins / immunology
Nerve Tissue Proteins / immunology
Protein-Tyrosine Kinases / immunology
Spores, Fungal / immunology
Syk Kinase
Transcription Factor AP-1 / biosynthesis*
beta-Glucans / immunology*
|
| IF |
2.914
|
| 引用数 |
16
|
|
WOS 分野
|
IMMUNOLOGY
MICROBIOLOGY
|
| リソース情報 |
| 病原微生物 |
IFM 49896
IFM 47042 |
