論文 - 詳細
| RRC ID | 31720 |
|---|---|
| 著者 | Yazawa K, Mikami Y, Maeda A, Akao M, Morisaki N, Iwasaki S. |
| タイトル | Inactivation of rifampin by Nocardia brasiliensis. |
| ジャーナル | Antimicrob Agents Chemother |
| Abstract |
Rifampin was glycosylated by a pathogenic species of Nocardia, i.e., Nocardia brasiliensis. The structures of two glycosylated compounds (RIP-1 and RIP-2) isolated from the culture broth of the bacterium were determined to be 3-formyl-23-(O-[beta-D-glucopyranosyl])rifamycin SV and 23-(O-[beta-D-glucopyranosyl])rifampin, respectively. Both compounds lacked antimicrobial activity against other gram-positive bacteria as well as the Nocardia species. |
| 巻・号 | 37(6) |
| ページ | 1313-7 |
| 公開日 | 1993-6-1 |
| DOI | 10.1128/AAC.37.6.1313 |
| PMID | 8328779 |
| PMC | PMC187958 |
| MeSH | Glycosylation Inactivation, Metabolic Magnetic Resonance Spectroscopy Mass Spectrometry Microbial Sensitivity Tests Nocardia / drug effects Nocardia / metabolism* Rifampin / metabolism Rifampin / pharmacokinetics* |
| IF | 4.904 |
| 引用数 | 41 |
| WOS 分野 | PHARMACOLOGY & PHARMACY MICROBIOLOGY |
| リソース情報 | |
| 病原微生物 | IFM 2057 IFM 0150 IFM 0236 IFM 0239 IFM 0284 IFM 0290 IFM 0319 |