RRC ID 31720
Author Yazawa K, Mikami Y, Maeda A, Akao M, Morisaki N, Iwasaki S.
Title Inactivation of rifampin by Nocardia brasiliensis.
Journal Antimicrob Agents Chemother
Abstract Rifampin was glycosylated by a pathogenic species of Nocardia, i.e., Nocardia brasiliensis. The structures of two glycosylated compounds (RIP-1 and RIP-2) isolated from the culture broth of the bacterium were determined to be 3-formyl-23-(O-[beta-D-glucopyranosyl])rifamycin SV and 23-(O-[beta-D-glucopyranosyl])rifampin, respectively. Both compounds lacked antimicrobial activity against other gram-positive bacteria as well as the Nocardia species.
Volume 37(6)
Pages 1313-7
Published 1993-6-1
DOI 10.1128/AAC.37.6.1313
PMID 8328779
PMC PMC187958
MeSH Glycosylation Inactivation, Metabolic Magnetic Resonance Spectroscopy Mass Spectrometry Microbial Sensitivity Tests Nocardia / drug effects Nocardia / metabolism* Rifampin / metabolism Rifampin / pharmacokinetics*
IF 4.904
Times Cited 41
Pathogenic microorganisms IFM 0150 IFM 0236 IFM 0239 IFM 0284 IFM 0290 IFM 0319 IFM 2057