論文 - 詳細
| RRC ID | 31722 |
|---|---|
| 著者 | Dabbs ER, Yazawa K, Mikami Y, Miyaji M, Morisaki N, Iwasaki S, Furihata K. |
| タイトル | Ribosylation by mycobacterial strains as a new mechanism of rifampin inactivation. |
| ジャーナル | Antimicrob Agents Chemother |
| Abstract |
Several fast-growing Mycobacterium strains were found to inactivate rifampin. Two inactivated compounds (RIP-Ma and RIP-Mb) produced by these organisms were different from previously reported derivatives, i.e., phosphorylated or glucosylated derivatives, of the antibiotic. The structures of RIP-Ma and RIP-Mb were determined to be those of 3-formyl-23-[O-(alpha-D-ribofuranosyl)]rifamycin SV and 23-[O-(alpha-D-ribofuranosyl)]rifampin, respectively. To our knowledge, this is the first known example of ribosylation as a mechanism of antibiotic inactivation. |
| 巻・号 | 39(4) |
| ページ | 1007-9 |
| 公開日 | 1995-4-1 |
| DOI | 10.1128/AAC.39.4.1007 |
| PMID | 7785970 |
| PMC | PMC162673 |
| MeSH | Inactivation, Metabolic Mycobacterium / metabolism* Rifampin / metabolism* |
| IF | 4.904 |
| 引用数 | 62 |
| WOS 分野 | PHARMACOLOGY & PHARMACY MICROBIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 各媒体での言及数の合計 | 0 |
| リソース情報 | |
| 病原微生物 | IFM 0359 |