| RRC ID |
31722
|
| Author |
Dabbs ER, Yazawa K, Mikami Y, Miyaji M, Morisaki N, Iwasaki S, Furihata K.
|
| Title |
Ribosylation by mycobacterial strains as a new mechanism of rifampin inactivation.
|
| Journal |
Antimicrob Agents Chemother
|
| Abstract |
Several fast-growing Mycobacterium strains were found to inactivate rifampin. Two inactivated compounds (RIP-Ma and RIP-Mb) produced by these organisms were different from previously reported derivatives, i.e., phosphorylated or glucosylated derivatives, of the antibiotic. The structures of RIP-Ma and RIP-Mb were determined to be those of 3-formyl-23-[O-(alpha-D-ribofuranosyl)]rifamycin SV and 23-[O-(alpha-D-ribofuranosyl)]rifampin, respectively. To our knowledge, this is the first known example of ribosylation as a mechanism of antibiotic inactivation.
|
| Volume |
39(4)
|
| Pages |
1007-9
|
| Published |
1995-4-1
|
| DOI |
10.1128/AAC.39.4.1007
|
| PMID |
7785970
|
| PMC |
PMC162673
|
| MeSH |
Inactivation, Metabolic
Mycobacterium / metabolism*
Rifampin / metabolism*
|
| IF |
4.904
|
| Times Cited |
62
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
MICROBIOLOGY
|
| Resource |
| Pathogenic microorganisms |
IFM 0359 |
