RRC ID 31754
Author Hosoe T, Nozawa K, Lumley TC, Currah RS, Fukushima K, Takizawa K, Miyaji M, Kawai K.
Title Tetranorditerpene lactones, potent antifungal antibiotics for human pathogenic yeasts, from a unique species of Oidiodendron.
Journal Chem Pharm Bull (Tokyo)
Abstract The culture filtrate of a fungus isolated from decaying Picea glauca wood and tentatively identified as Oidiodendron cf. truncatum showed strong antibiotic activity against the pathogenic yeast, Candida albicans. Four new tetranorditerpenoids, oidiodendrolides A (3), B (4), and C (5) and oidiodendronic acid (7) were isolated along with three known tetranorditerpenoids, LL-Z1271 alpha (= PR1387) (1), PR1388 (2), and acrostalidic acid (6), from rice fermented by the above fungus. The structures of oidiodendrolides A (3), B (4), and C (5) and oidiodendronic acid (7) were established on the basis of spectroscopic and chemical investigations. The antifungal activity of the above tetranorditerpenoids against the pathogenic yeasts, Candida albicans and Cryptococcus neoformans is discussed.
Volume 47(11)
Pages 1591-7
Published 1999-11-1
DOI 10.1248/cpb.47.1591
PMID 10605057
MeSH Antifungal Agents / chemistry Antifungal Agents / isolation & purification* Antifungal Agents / pharmacology Candida albicans / drug effects Cryptococcus neoformans / drug effects Diterpenes / chemistry Diterpenes / isolation & purification* Diterpenes / pharmacology Fungi / chemistry* Humans Lactones / chemistry Lactones / isolation & purification* Lactones / pharmacology Microbial Sensitivity Tests Molecular Structure Saccharomyces cerevisiae / drug effects
IF 1.416
Times Cited 20
Pathogenic microorganisms IFM 40213 IFM 40214 IFM 40215 IFM 41243 IFM 41934 IFM 46816 IFM 46823 IFM 46863 IFM 46921 IFM 47182 IFM 47321 IFM 47328 IFM 47343 IFM 47347 IFM 47945 IFM 48313 IFM 48430