| RRC ID |
31758
|
| Author |
Hirano K, Kubota T, Tsuda M, Mikami Y, Kobayashi J.
|
| Title |
Pyrinodemins B-D, potent cytotoxic bis-pyridine alkaloids from marine sponge amphimedon sp.
|
| Journal |
Chem Pharm Bull (Tokyo)
|
| Abstract |
New bis-pyridine alkaloids, pyrinodemins B-D (1-3), have been isolated together with pyrinodemin A (4) and related 3-alkyl pyridine alkaloids 5-8 from the Okinawan marine sponge Amphimedon sp. and the structures were elucidated from spectroscopic data. Pyrinodemins B-D (1-3) showed potent cytotoxicity, while compounds 5-8 exhibited antimicrobial activity.
|
| Volume |
48(7)
|
| Pages |
974-7
|
| Published |
2000-7-1
|
| DOI |
10.1248/cpb.48.974
|
| PMID |
10923825
|
| MeSH |
Alkaloids / chemistry
Alkaloids / isolation & purification*
Alkaloids / pharmacology
Animals
Anti-Bacterial Agents
Anti-Infective Agents / chemistry
Anti-Infective Agents / isolation & purification*
Anti-Infective Agents / pharmacology
Bacteria / drug effects
Candida albicans / drug effects
Porifera / chemistry*
Pyridines / chemistry
Pyridines / isolation & purification
Pyridines / pharmacology
|
| IF |
1.416
|
| Times Cited |
46
|
|
WOS Category
|
CHEMISTRY, MULTIDISCIPLINARY
CHEMISTRY, MEDICINAL
PHARMACOLOGY & PHARMACY
|
| Resource |
| Pathogenic microorganisms |
IFM 2057
IFM 40213
IFM 40215 |
