| RRC ID |
31809
|
| Author |
Takeo K, Yarita K, Yoshida S, Guan HQ, Nishimura K, Miyaji M.
|
| Title |
Rapid, extensive and reversible vacuolation of Schizosaccharomyces pombe induced by amphotericin B.
|
| Journal |
FEMS Microbiol Lett
|
| Abstract |
The fission yeast Schizosaccharomyces pombe has no large vacuoles under normal growth conditions, although budding yeasts usually have large central vacuoles. The minimum inhibitory concentration of amphotericin B to S. pombe was 0.5 microgram ml-1; treatment with 0.2 microgram ml-1 for 20 min induced rapid and extensive vacuolation in S. pombe exponential phase cells. Growth rate of the cells with 0.2 microgram ml-1 amphotericin B was much reduced for 6 h, showing extensive vacuolation. Vacuolation in itself was not fatal: on removal of the drug, most cells recovered gradually and eventually multiplied.
|
| Volume |
108(3)
|
| Pages |
265-9
|
| Published |
1993-4-15
|
| DOI |
10.1111/j.1574-6968.1993.tb06113.x
|
| PMID |
8514114
|
| MeSH |
Amphotericin B / pharmacology*
Cell Membrane / drug effects
Dose-Response Relationship, Drug
Schizosaccharomyces / drug effects*
Schizosaccharomyces / growth & development
Schizosaccharomyces / ultrastructure
Vacuoles / drug effects*
|
| IF |
1.987
|
| Times Cited |
2
|
|
WOS Category
|
MICROBIOLOGY
|
| Resource |
| Pathogenic microorganisms |
IFM 40190 |
