Reference - Detail
| RRC ID | 31813 |
|---|---|
| Author | Ohkusu M, Raclavsky V, Takeo K. |
| Title | Deficit in oxygen causes G(2) budding and unbudded G(2) arrest in Cryptococcus neoformans. |
| Journal | FEMS Microbiol Lett |
| Abstract |
Cryptococcus neoformans exhibited diphasic growth when grown under limited aeration. First, it grew exponentially, but at OD 1, the concentration of dissolved oxygen in culture decreased to 1 mg l(-1) and a second phase of slow growth was started. This phase was characterized by a shift of budding from S to G(2), a sharp decrease in budding index and a sharp increase in the proportion of unbudded G(2) cells to 80%. Thus, a deficit in oxygen was demonstrated to delay the timing of budding, prolong the G(2) phase and cause accumulation of cells after DNA synthesis, but before commitment to budding. |
| Volume | 204(1) |
| Pages | 29-32 |
| Published | 2001-10-16 |
| DOI | 10.1111/j.1574-6968.2001.tb10857.x |
| PII | S0378-1097(01)00370-6 |
| PMID | 11682173 |
| MeSH | Cell Cycle Cryptococcus neoformans / cytology Cryptococcus neoformans / drug effects* Cryptococcus neoformans / growth & development* Culture Media DNA, Fungal / analysis G2 Phase / drug effects* Glucose / metabolism Oxygen / metabolism Oxygen / pharmacology* |
| IF | 1.987 |
| Times Cited | 15 |
| WOS Category | MICROBIOLOGY |
| Resource | |
| Pathogenic microorganisms | IFM 49144 |