| RRC ID |
31856
|
| Author |
Tanaka Y, Komaki H, Yazawa K, Mikami Y, Nemoto A, Tojyo T, Kadowaki K, Shigemori H, Kobayashi J.
|
| Title |
Brasilinolide A, a new macrolide antibiotic produced by Nocardia brasiliensis: producing strain, isolation and biological activity.
|
| Journal |
J Antibiot (Tokyo)
|
| Abstract |
A new 32-membered macrolide antibiotic, brasilinolide A was isolated from the fermentation broth of Nocardia sp. IFM 0406. The producer was identified as Nocardia brasiliensis. The antibiotic was only active against Aspergillus niger, but not active against other fungi including yeasts as well as other filamentous like fungi and bacteria. Brasilinolide A exerted an immunosuppressive activity in the assay system of a mixed lymphocyte reaction (MLR).
|
| Volume |
50(12)
|
| Pages |
1036-41
|
| Published |
1997-12-1
|
| DOI |
10.7164/antibiotics.50.1036
|
| PMID |
9510911
|
| MeSH |
Animals
Anti-Bacterial Agents / biosynthesis
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / pharmacology
Bacteria / drug effects
Cells, Cultured / drug effects
Culture Media
Fungi / drug effects
HeLa Cells / drug effects
Humans
Macrolides / chemistry*
Macrolides / isolation & purification*
Macrolides / pharmacology
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Nocardia / chemistry*
Nocardia / classification
|
| IF |
2.668
|
| Times Cited |
45
|
|
WOS Category
|
PHARMACOLOGY & PHARMACY
BIOTECHNOLOGY & APPLIED MICROBIOLOGY
IMMUNOLOGY
MICROBIOLOGY
|
| Resource |
| Pathogenic microorganisms |
IFM 40081
IFM 41994
IFM 40606
IFM 0236
IFM 0333
IFM 0406 |
