論文 - 詳細
| RRC ID | 31872 |
|---|---|
| 著者 | Marchingo JM, Kan A, Sutherland RM, Duffy KR, Wellard CJ, Belz GT, Lew AM, Dowling MR, Heinzel S, Hodgkin PD. |
| タイトル | T cell signaling. Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion. |
| ジャーナル | Science |
| Abstract |
T cell responses are initiated by antigen and promoted by a range of costimulatory signals. Understanding how T cells integrate alternative signal combinations and make decisions affecting immune response strength or tolerance poses a considerable theoretical challenge. Here, we report that T cell receptor (TCR) and costimulatory signals imprint an early, cell-intrinsic, division fate, whereby cells effectively count through generations before returning automatically to a quiescent state. This autonomous program can be extended by cytokines. Signals from the TCR, costimulatory receptors, and cytokines add together using a linear division calculus, allowing the strength of a T cell response to be predicted from the sum of the underlying signal components. These data resolve a long-standing costimulation paradox and provide a quantitative paradigm for therapeutically manipulating immune response strength. |
| 巻・号 | 346(6213) |
| ページ | 1123-7 |
| 公開日 | 2014-11-28 |
| DOI | 10.1126/science.1260044 |
| PII | 346/6213/1123 |
| PMID | 25430770 |
| MeSH | Animals Antigens / immunology* CD8-Positive T-Lymphocytes / cytology CD8-Positive T-Lymphocytes / immunology* Cell Division Cell Proliferation Cytokines / immunology* Immune Tolerance* Lymphocyte Activation Mice Receptors, Antigen, T-Cell / immunology* Signal Transduction |
| IF | 41.846 |
| 引用数 | 102 |
| WOS 分野 | IMMUNOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 22 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC02705 RBRC02709 |