論文 - 詳細
| RRC ID | 31873 |
|---|---|
| 著者 | Hussain Z, Katas H, Mohd Amin MC, Kumolosasi E. |
| タイトル | Efficient immuno-modulation of TH1/TH2 biomarkers in 2,4-dinitrofluorobenzene-induced atopic dermatitis: nanocarrier-mediated transcutaneous co-delivery of anti-inflammatory and antioxidant drugs. |
| ジャーナル | PLoS One |
| Abstract |
The present study was conducted with the aim to investigate the immuno-modulatory and histological stabilization effects of nanocarrier-based transcutaneous co-delivery of hydrocortisone (HC) and hydroxytyrosol (HT). In this investigation, the clinical and pharmacological efficacies of nanoparticle (NP)-based formulation to alleviate 2,4-dinitrofluorobenzene (DNFB)-induced atopic dermatitis (AD) was explored by using an NC/Nga mouse model. Ex vivo visual examination of AD induction in experimental mice indicated remarkable control of NP-based formulations in reducing pathological severity of AD-like skin lesions. Therapeutic effectiveness of NP-based formulations was also evaluated by comparing skin thickness of AD-induced NP-treated mice (456±27 µm) with that of atopic mice (916±37 µm). Analysis of the immuno-spectrum of AD also revealed the dominance of NP-based formulations in restraining immunoglobulin-E (IgE), histamine, prostaglandin-E2 (PGE2), vascular endothelial growth factor-α (VEGF-α), and T-helper cells (TH1/TH2) producing cytokines in serum and skin biopsies of tested mice. These anti-AD data were further supported by histological findings that revealed alleviated pathological features, including collagen fiber deposition, fibroblasts infiltration, and fragmentation of elastic fibers in experimental mice. Thus, NP-mediated transcutaneous co-delivery of HC and HT can be considered as a promising therapy for managing immunological and histological spectra associated with AD. |
| 巻・号 | 9(11) |
| ページ | e113143 |
| 公開日 | 2014-1-1 |
| DOI | 10.1371/journal.pone.0113143 |
| PII | PONE-D-14-22182 |
| PMID | 25396426 |
| PMC | PMC4232601 |
| MeSH | Administration, Cutaneous Animals Anti-Inflammatory Agents / administration & dosage* Antioxidants / administration & dosage* Biomarkers / metabolism Cytokines / blood Dermatitis, Atopic / chemically induced Dermatitis, Atopic / drug therapy* Dermatitis, Atopic / pathology Dinitrofluorobenzene / toxicity Dinoprostone / analysis Dinoprostone / blood Disease Models, Animal Drug Carriers / chemistry Histamine / analysis Histamine / blood Hydrocortisone / administration & dosage Immunoglobulin E / analysis Immunoglobulin E / blood Mice Nanoparticles / chemistry* Phenylethyl Alcohol / administration & dosage Phenylethyl Alcohol / analogs & derivatives Skin / pathology Th1 Cells / immunology Th1 Cells / metabolism* Th2 Cells / immunology Th2 Cells / metabolism* Vascular Endothelial Growth Factor A / analysis Vascular Endothelial Growth Factor A / blood |
| IF | 2.74 |
| 引用数 | 14 |
| WOS 分野 | PHARMACOLOGY & PHARMACY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 2 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 実験動物マウス | RBRC01059 |