RRC ID 31877
Author Obata Y, Kimura S, Nakato G, Iizuka K, Miyagawa Y, Nakamura Y, Furusawa Y, Sugiyama M, Suzuki K, Ebisawa M, Fujimura Y, Yoshida H, Iwanaga T, Hase K, Ohno H.
Title Epithelial-stromal interaction via Notch signaling is essential for the full maturation of gut-associated lymphoid tissues.
Journal EMBO Rep
Abstract Intrinsic Notch signaling in intestinal epithelial cells restricts secretory cell differentiation. In gut-associated lymphoid tissue (GALT), stromal cells located beneath the follicle-associated epithelium (FAE) abundantly express the Notch ligand delta-like 1 (Dll1). Here, we show that mice lacking Rbpj-a gene encoding a transcription factor implicated in Notch signaling-in intestinal epithelial cells have defective GALT maturation. This defect can be attributed to the expansion of goblet cells, which leads to the down-regulation of CCL20 in FAE. These data demonstrate that epithelial Notch signaling maintained by stromal cells contributes to the full maturation of GALT by restricting secretory cell differentiation in FAE.
Volume 15(12)
Pages 1297-304
Published 2014-12-1
DOI 10.15252/embr.201438942
PII embr.201438942
PMID 25378482
PMC PMC4264932
MeSH Animals Cell Differentiation / physiology Epithelial Cells / cytology* Epithelial Cells / metabolism* In Vitro Techniques Intestinal Mucosa / cytology Intestinal Mucosa / metabolism Lymphoid Tissue / cytology* Lymphoid Tissue / metabolism* Mice Receptors, Notch / metabolism* Signal Transduction / physiology Stromal Cells / cytology* Stromal Cells / metabolism
IF 7.497
Times Cited 6
Mice RBRC01071