論文 - 詳細
| RRC ID | 31877 |
|---|---|
| 著者 | Obata Y, Kimura S, Nakato G, Iizuka K, Miyagawa Y, Nakamura Y, Furusawa Y, Sugiyama M, Suzuki K, Ebisawa M, Fujimura Y, Yoshida H, Iwanaga T, Hase K, Ohno H. |
| タイトル | Epithelial-stromal interaction via Notch signaling is essential for the full maturation of gut-associated lymphoid tissues. |
| ジャーナル | EMBO Rep |
| Abstract |
Intrinsic Notch signaling in intestinal epithelial cells restricts secretory cell differentiation. In gut-associated lymphoid tissue (GALT), stromal cells located beneath the follicle-associated epithelium (FAE) abundantly express the Notch ligand delta-like 1 (Dll1). Here, we show that mice lacking Rbpj-a gene encoding a transcription factor implicated in Notch signaling-in intestinal epithelial cells have defective GALT maturation. This defect can be attributed to the expansion of goblet cells, which leads to the down-regulation of CCL20 in FAE. These data demonstrate that epithelial Notch signaling maintained by stromal cells contributes to the full maturation of GALT by restricting secretory cell differentiation in FAE. |
| 巻・号 | 15(12) |
| ページ | 1297-304 |
| 公開日 | 2014-12-1 |
| DOI | 10.15252/embr.201438942 |
| PII | embr.201438942 |
| PMID | 25378482 |
| PMC | PMC4264932 |
| MeSH | Animals Cell Differentiation / physiology Epithelial Cells / cytology* Epithelial Cells / metabolism* In Vitro Techniques Intestinal Mucosa / cytology Intestinal Mucosa / metabolism Lymphoid Tissue / cytology* Lymphoid Tissue / metabolism* Mice Receptors, Notch / metabolism* Signal Transduction / physiology Stromal Cells / cytology* Stromal Cells / metabolism |
| IF | 7.497 |
| 引用数 | 6 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| 実験動物マウス | RBRC01071 |