| RRC ID |
31891
|
| 著者 |
Morisaki N, Hashimoto Y, Furihata K, Yazawa K, Tamura M, Mikami Y.
|
| タイトル |
Glycosylative inactivation of chalcomycin and tylosin by a clinically isolated Nocardia asteroides strain.
|
| ジャーナル |
J Antibiot (Tokyo)
|
| Abstract |
Studies on the susceptibility of pathogenic Nocardia to macrolide antibiotics, chalcomycin and tylosin, showed that most of the Nocardia species examined were highly resistant to both antibiotics, although N. nova was moderately susceptible. N. asteroides IFM 0339 converted these macrolides into inactive metabolites by glycosylation at 2'-OH or glycosylation and reduction of the 20-formyl group. The structures of the metabolites were determined from NMR and MS data to be 2'-[O-(beta-D-glucopyranosyl)]chalcomycin (2), 2'-[O-(beta-D-glucopyranosyl)]tylosin (5) and 20-dihydro-2'-[O-(beta-D-glucopyranosyl)]tylosin (4).
|
| 巻・号 |
54(2)
|
| ページ |
157-65
|
| 公開日 |
2001-2-1
|
| DOI |
10.7164/antibiotics.54.157
|
| PMID |
11302489
|
| MeSH |
Anti-Bacterial Agents / antagonists & inhibitors*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / metabolism
Glycosylation
Macrolides*
Magnetic Resonance Spectroscopy
Mass Spectrometry
Molecular Structure
Nocardia asteroides / physiology*
Spectrometry, Mass, Fast Atom Bombardment
Tylosin / antagonists & inhibitors*
Tylosin / chemistry
Tylosin / metabolism
|
| IF |
2.668
|
| 引用数 |
7
|
| リソース情報 |
| 病原微生物 |
IFM 0192
IFM 0205
IFM 0221
IFM 0228
IFM 0236
IFM 0239
IFM 0246
IFM 0249
IFM 0256
IFM 0258
IFM 0262
IFM 0274
IFM 0275
IFM 0279
IFM 0280
IFM 0284
IFM 0290
IFM 0294
IFM 0297
IFM 0299
IFM 0300
IFM 0303
IFM 0319
IFM 0320
IFM 0337
IFM 0339
IFM 0347
IFM 0356 |
