Reference - Detail
| RRC ID | 31926 |
|---|---|
| Author | Fukai T, Yonekawa M, Hou AJ, Nomura T, Sun HD, Uno J. |
| Title | Antifungal agents from the roots of Cudrania cochinchinensis against Candida, Cryptococcus, and Aspergillus species. |
| Journal | J Nat Prod |
| Abstract |
Bioassay-guided fractionation resulted in the isolation of four antifungal agents from the roots of Cudrania cochinchinensis. Two of these were new compounds, cudraxanthone S [1, 1,3,5,6-tetrahydroxy-2-(1,1-dimethyl-2-propenyl)xanthone] and cudraflavanone B (2, 2',4',5,7-tetrahydroxy-6-prenylflavanone). The remaining two compounds were known compounds, toxyloxanthone C (3) and wighteone (4). Among these compounds, 1, 3, and 4 exhibited antifungal activities against Cryptococcus neoformans, Aspergillusfumigatus, and A. nidulans (MICs = 2-8 microg/mL). Compounds 1 and 3 also showed antifungal activity against Candida glabrata (MICs = 4-8 microg/mL). |
| Volume | 66(8) |
| Pages | 1118-20 |
| Published | 2003-8-1 |
| DOI | 10.1021/np030024u |
| PMID | 12932139 |
| MeSH | Antifungal Agents / chemistry Antifungal Agents / isolation & purification* Antifungal Agents / pharmacology Aspergillus / drug effects* Candida / drug effects* Cryptococcus / drug effects* Drugs, Chinese Herbal / chemistry Drugs, Chinese Herbal / isolation & purification* Drugs, Chinese Herbal / pharmacology Molecular Structure Moraceae / chemistry* Plant Roots / chemistry Xanthones / chemistry Xanthones / isolation & purification* Xanthones / pharmacology |
| IF | 3.782 |
| Times Cited | 42 |
| WOS Category | PHARMACOLOGY & PHARMACY CHEMISTRY, MEDICINAL PLANT SCIENCES |
| Resource | |
| Pathogenic microorganisms | IFM 5369 IFM 5774 IFM 5798 IFM 40205 IFM 40213 IFM 40215 IFM 40217 IFM 41236 IFM 41374 IFM 46829 |