RRC ID 31942
Author Taniguchi Y, Taketani T, Moriyama H, Moriki S, Nishimura K, Sato E, Notsu Y, Higuchi T, Sugitani Y, Yasuda K, Nagai A, Yamaguchi S, Shibata H, Masuda J.
Title Septic shock induced by Lecythophora mutabilis in a patient with mitochondrial encephalomyopathy.
Journal J Med Microbiol
Abstract Invasive fungal infection (IFI) caused by Lecythophora mutabilis occasionally occurs in patients with impaired host immunity; such patients had eosinophilia at onset, and surviving patients were treated with fungal cell-membrane-targeted drugs. An 18-year-old man with mitochondrial encephalomyopathy accompanied with refractory anaemia and chronic renal failure developed septic shock caused by L. mutabilis, which was detected from a blood culture, and was identified morphologically and genetically. During the course of the infection, he had eosinophilia, although beta-d-glucan levels were within the normal range. He was treated with micafungin, but deteriorated and died, despite his treatment being changed to liposomal amphotericin B. On the basis of this we suggest that IFI caused by L. mutabilis should be suspected when a compromised host develops infection and eosinophilia, and that antifungal drugs that target beta-d-glucan are not advisable.
Volume 58(Pt 9)
Pages 1255-1258
Published 2009-9-1
DOI 10.1099/jmm.0.010678-0
PMID 19528157
MeSH Adolescent Amphotericin B / therapeutic use Antifungal Agents / therapeutic use Ascomycota / drug effects Ascomycota / isolation & purification* Ascomycota / pathogenicity Echinocandins / therapeutic use Humans Insomnia, Fatal Familial Lipopeptides / therapeutic use Male Micafungin Mitochondrial Encephalomyopathies / complications* Mycoses / complications* Mycoses / drug therapy Mycoses / microbiology* Pneumonia, Aspiration / complications Pneumonia, Aspiration / microbiology Shock, Septic / complications* Shock, Septic / microbiology*
IF 2.156
Times Cited 6
Pathogenic microorganisms IFM 58001