| RRC ID |
31999
|
| Author |
Motomura Y, Morita H, Moro K, Nakae S, Artis D, Endo TA, Kuroki Y, Ohara O, Koyasu S, Kubo M.
|
| Title |
Basophil-derived interleukin-4 controls the function of natural helper cells, a member of ILC2s, in lung inflammation.
|
| Journal |
Immunity
|
| Abstract |
Allergic asthma is an inflammatory disease characterized by lung eosinophilia controlled by type 2 cytokines. Cysteine proteases are potent triggers of allergic inflammation by causing barrier disruption in lung epithelial cells inducing the elevation of interleukin-5 (IL-5) and IL-13 from natural helper (NH) cells, a member of ILC2s, which leads to lung eosinophilia. In this study, we found that basophils play a crucial role in NH cell-mediated eosinophilic inflammation induced by protease allergens. Conditional deletion of basophils caused a resolution of the papain-induced eosinophilia and mucus production. Resolution of eosinophilia was also observed in mice lacking IL-4 specifically in basophils, indicating that basophil-derived IL-4 enhanced expression of the chemokine CCL11, as well as IL-5, IL-9, and IL-13 in NH cells, thus attracting eosinophils. These results demonstrate that IL-4 from basophils has an important role in the NH-derived cytokine and chemokine expression, subsequently leading to protease allergen-induced airway inflammation.
|
| Volume |
40(5)
|
| Pages |
758-71
|
| Published |
2014-5-15
|
| DOI |
10.1016/j.immuni.2014.04.013
|
| PII |
S1074-7613(14)00151-4
|
| PMID |
24837103
|
| MeSH |
Animals
Asthma / immunology
Basophils / immunology*
Chemokine CCL11 / biosynthesis
Eosinophils / immunology*
Interleukin-13 / biosynthesis
Interleukin-13 / immunology*
Interleukin-4 / deficiency
Interleukin-4 / genetics
Interleukin-4 / immunology*
Interleukin-5 / biosynthesis
Interleukin-5 / immunology*
Interleukin-9 / biosynthesis
Interleukin-9 / immunology
Mice
Mice, Inbred C57BL
Mice, Knockout
Pneumonia / immunology
Pulmonary Eosinophilia / immunology
T-Lymphocytes, Helper-Inducer / immunology
|
| IF |
22.553
|
| Times Cited |
165
|
|
WOS Category
|
IMMUNOLOGY
|
| Resource |
| Mice |
RBRC02298 |
