Reference - Detail
| RRC ID | 31999 |
|---|---|
| Author | Motomura Y, Morita H, Moro K, Nakae S, Artis D, Endo TA, Kuroki Y, Ohara O, Koyasu S, Kubo M. |
| Title | Basophil-derived interleukin-4 controls the function of natural helper cells, a member of ILC2s, in lung inflammation. |
| Journal | Immunity |
| Abstract |
Allergic asthma is an inflammatory disease characterized by lung eosinophilia controlled by type 2 cytokines. Cysteine proteases are potent triggers of allergic inflammation by causing barrier disruption in lung epithelial cells inducing the elevation of interleukin-5 (IL-5) and IL-13 from natural helper (NH) cells, a member of ILC2s, which leads to lung eosinophilia. In this study, we found that basophils play a crucial role in NH cell-mediated eosinophilic inflammation induced by protease allergens. Conditional deletion of basophils caused a resolution of the papain-induced eosinophilia and mucus production. Resolution of eosinophilia was also observed in mice lacking IL-4 specifically in basophils, indicating that basophil-derived IL-4 enhanced expression of the chemokine CCL11, as well as IL-5, IL-9, and IL-13 in NH cells, thus attracting eosinophils. These results demonstrate that IL-4 from basophils has an important role in the NH-derived cytokine and chemokine expression, subsequently leading to protease allergen-induced airway inflammation. |
| Volume | 40(5) |
| Pages | 758-71 |
| Published | 2014-5-15 |
| DOI | 10.1016/j.immuni.2014.04.013 |
| PII | S1074-7613(14)00151-4 |
| PMID | 24837103 |
| MeSH | Animals Asthma / immunology Basophils / immunology* Chemokine CCL11 / biosynthesis Eosinophils / immunology* Interleukin-13 / biosynthesis Interleukin-13 / immunology* Interleukin-4 / deficiency Interleukin-4 / genetics Interleukin-4 / immunology* Interleukin-5 / biosynthesis Interleukin-5 / immunology* Interleukin-9 / biosynthesis Interleukin-9 / immunology Mice Mice, Inbred C57BL Mice, Knockout Pneumonia / immunology Pulmonary Eosinophilia / immunology T-Lymphocytes, Helper-Inducer / immunology |
| IF | 22.553 |
| Times Cited | 165 |
| WOS Category | IMMUNOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 7 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Mice | RBRC02298 |