RRC ID 32080
Author Oishi S, Watanabe MF.
Title Acute toxicity of Microcystis aeruginosa and its cardiovascular effects.
Journal Environ Res
Abstract The acute toxicity of a water extract from unialgal-cultured blue-green alga Microcystis aeruginosa M228 on mice and rats was studied. The mice intraperitoneally injected with the extract became lethargic and piloerection was seen. Terminally their ears, tails, limbs, and eyes became chalky white. The LD50 value of the extract for mice was estimated at 14.4 mg dry wt of cells/kg and that of rats was 67.4 mg/kg. Tachycardia was shown in the mice injected with the extract. A value of LD50 of coadministration of the extract and phenoxybenzamine in mice was significantly larger than that of the extract alone and survival time of mice injected with the extract and phenoxybenzamine was prolonged. These results suggest that the extract of the alga may take the acute toxic effects via the sympathetic nervous system.
Volume 40(2)
Pages 518-24
Published 1986-8-1
DOI 10.1016/s0013-9351(86)80126-8
PII S0013-9351(86)80126-8
PMID 3089773
MeSH Animals Body Weight Bradycardia / etiology Injections, Intraperitoneal Lethal Dose 50 Male Mice Mice, Inbred ICR Microcystis / pathogenicity* Organ Size Rats Rats, Inbred Strains Species Specificity Tachycardia / etiology*
IF 5.715
Times Cited 19
Algae NIES-3349