Reference - Detail
| RRC ID | 32197 |
|---|---|
| Author | Biswas SK, Yokoyama K, Kamei K, Nishimura K, Miyaji M. |
| Title | Inhibition of hyphal growth of Candida albicans by activated lansoprazole, a novel benzimidazole proton pump inhibitor. |
| Journal | Med Mycol |
| Abstract |
The effect of activated lansoprazole (AG 2000), a novel benzimidazole proton pump inhibitor, against hypha formation of Candida albicans was examined in hypha-forming medium pH 7 (HFM7) after 20 h. AG 2000, at 50-800 microM, did not inhibit germ tube formation. However, it inhibited elongation of germ tubes to form hyphae and favored conversion of germ tubes to resume yeast growth at concentrations of > or =200 microM. Pre-treatment of AG 2000 with a sulfhydryl reagent (1:1), such as 2-mercaptoethanol. blocked the inhibitory property of AG 2000 on hypha formation. |
| Volume | 39(3) |
| Pages | 283-5 |
| Published | 2001-6-1 |
| DOI | 10.1080/mmy.39.3.283.285 |
| PMID | 11446532 |
| MeSH | 2-Pyridinylmethylsulfinylbenzimidazoles Antifungal Agents / pharmacology* Benzimidazoles / pharmacology* Candida albicans / drug effects* Candida albicans / growth & development Culture Media Humans Lansoprazole Omeprazole / analogs & derivatives* Omeprazole / pharmacology* Proton Pump Inhibitors* |
| IF | 2.822 |
| Times Cited | 15 |
| WOS Category | VETERINARY SCIENCES MYCOLOGY INFECTIOUS DISEASES |
| Resource | |
| Pathogenic microorganisms | IFM 40009 IFM 40101 IFM 47259 |