RRC ID 32205
著者 Sugiyama K, Sano A, Murakami M, Ogawa T, Mishima H, Otake H, Kamei K, Sugiyama S.
タイトル Three isolations of Chaetomium globosum from erythematous epilation of canine skin.
ジャーナル Med Mycol
Abstract Chaetomium globosum is commonly found in natural environments worldwide and is known to be a causative agent for emerging fungal infections. The present study describes a case of erythematous epilation of a dog caused by C. globosum. A mixed-breed young dog, a 4-months-old male, weighing 7.25 kg, showed depilation, scales, and dermatitis with slightly itchiness on his skin. The main symptom was an erythematous epilation on the left subocular skin 7.5 cm in diameter, accompanied by elephantiasis-like hyperplasia and scales. Similar lesions were observed on the skin on both sides of the ear lobes, the heels, tail, and left angulus oris. The scales from the crusted lesion were cultured on chrolamphenicole-added potato dextrose agar plates at the first visit, as well as followed by ambulatory practices. The isolates at the first visit, 1 and 3 weeks after treatment, were identified as C. globosum by mycological study and the D1/D2 domain of the large subunit rRNA gene sequence. The patient dog was treated by ketoconzole both orally and externally. The lesions were cured, showing new hair growth 9 weeks later. In addition, the susceptibilities to antifungal agents for the present C. globosum isolate were as follows: amphotericin B, 4.0 microg/ml; 5-FC 64.0 microg/ml; itraconazole, 0.5 microg/ml; miconazole, 1.0 microg/ml; fulconazole, 16.0 microg/ml; ketoconazole, 0.25 microg/ml; and micafungin, 16.0 microg/ml.
巻・号 46(5)
ページ 505-10
公開日 2008-8-1
DOI 10.1080/13693780801968555
PII 791408132
PMID 18608918
MeSH Animals Antifungal Agents / administration & dosage Antifungal Agents / therapeutic use Chaetomium / isolation & purification* DNA, Fungal / chemistry DNA, Fungal / genetics DNA, Ribosomal / chemistry DNA, Ribosomal / genetics Dermatomycoses / drug therapy Dermatomycoses / microbiology* Dermatomycoses / pathology Dermatomycoses / veterinary* Dog Diseases / drug therapy Dog Diseases / microbiology* Dog Diseases / pathology Dogs Focal Epithelial Hyperplasia Genes, rRNA Male Molecular Sequence Data Phylogeny RNA, Fungal / genetics RNA, Ribosomal / genetics Sequence Analysis, DNA
IF 2.822
引用数 5
WOS 分野 VETERINARY SCIENCES MYCOLOGY INFECTIOUS DISEASES
リソース情報
病原微生物 IFM 40213 IFM 53574