| RRC ID |
32209
|
| 著者 |
Iwasawa MT, Togawa Y, Akita F, Kambe N, Matsue H, Yaguchi T, Nishimura K.
|
| タイトル |
Kerion celsi due to Arthroderma incurvatum infection in a Sri Lankan child: species identification and analysis of area-dependent genetic polymorphism.
|
| ジャーナル |
Med Mycol
|
| Abstract |
A three-year-old Sri Lankan boy residing in Japan developed a nodule on his scalp after visiting Sri Lanka. Two months later, the lesion increased in size to 22 × 19 mm(2), and was identified as an erythematous nodule with alopecia. Direct examination of the infected hair shafts indicated fungal hyphae outside the shafts. The fungus was identified as Microsporum gypseum following mycological examination. The sequence of the internal transcribed spacer 1 region of ribosomal RNA gene (ITS1 rDNA) exhibited 95.7-100.0% homology with that of Arthroderma incurvatum. The patient was successfully treated with a 6-week itraconazole course. We also examined DNA samples from eight clinical isolates of A. incurvatum. Alignments of ITS1 sequences of these strains and our isolate, showed gaps in the 64-bp positions 140-142 and 141-143 of the 205-207-bp ITS1 alignment. We performed phylogenetic analysis using the neighbor-jointing (NJ) method based on the ITS1 sequences of the present isolate and twenty related strains. Fifteen A. incurvatum strains were divided into East Asia and non-East Asia clusters. The present isolate belonged to the non-East Asia cluster, suggesting that the patient was infected outside Japan. Moreover, the trees suggested area-dependent genetic polymorphism of A. incurvatum.
|
| 巻・号 |
50(7)
|
| ページ |
690-8
|
| 公開日 |
2012-10-1
|
| DOI |
10.3109/13693786.2012.671968
|
| PMID |
22443310
|
| MeSH |
Antifungal Agents / administration & dosage
Arthrodermataceae / isolation & purification*
Base Sequence
Child, Preschool
Cluster Analysis
DNA, Fungal / chemistry
DNA, Fungal / genetics
DNA, Ribosomal / chemistry
DNA, Ribosomal / genetics
DNA, Ribosomal Spacer / chemistry
DNA, Ribosomal Spacer / genetics
Humans
Itraconazole / administration & dosage
Japan
Male
Microscopy
Molecular Sequence Data
Phylogeography*
Polymorphism, Genetic*
Scalp / pathology
Sequence Alignment
Sequence Analysis, DNA
Sri Lanka
Tinea Capitis / diagnosis*
Tinea Capitis / microbiology*
Treatment Outcome
|
| IF |
2.822
|
| 引用数 |
8
|
|
WOS 分野
|
VETERINARY SCIENCES
MYCOLOGY
INFECTIOUS DISEASES
|
| リソース情報 |
| 病原微生物 |
IFM 5305
IFM 5306
IFM 5308
IFM 5309
IFM 5310
IFM 46456
IFM 46457
IFM 46928
IFM 47488
IFM 47490
IFM 47491
IFM 47492
IFM 48151
IFM 48152
IFM 49903
IFM 49904
IFM 53877
IFM 53930
IFM 59508 |
| 一般微生物 |
JCM 1905
JCM 1906 |
