RRC ID |
32227
|
Author |
Tanaka Y, Yazawa K, Dabbs ER, Nishikawa K, Komaki H, Mikami Y, Miyaji M, Morisaki N, Iwasaki S.
|
Title |
Different rifampicin inactivation mechanisms in Nocardia and related taxa.
|
Journal |
Microbiol Immunol
|
Abstract |
Mycolic acid-containing bacteria inactivate rifampicin in a variety of ways such as glucosylation, ribosylation, phosphorylation and decolorization. These inactivations were found to be a species-specific phenomena in Nocardia and related taxa. Gordona, Tsukamurella and fast-growing Mycobacterium modified rifampicin by ribosylation of the 23-OH group of the antibiotic. Such ribosylation was not observed in Rhodococcus and Corynebacterium, but phosphorylation of the 21-OH group of rifampicin was observed in one strain of Rhodococcus. Nocardia modified the antibiotic by glucosylation (23-OH group) and phosphorylation, but ribosylation was not observed.
|
Volume |
40(1)
|
Pages |
1-4
|
Published |
1996-1-1
|
DOI |
10.1111/j.1348-0421.1996.tb03303.x
|
PMID |
8871521
|
MeSH |
Actinomycetales / drug effects*
Actinomycetales / metabolism
Drug Resistance, Microbial
Glycosylation
Microbial Sensitivity Tests
Phosphorylation
Rifampin / chemistry
Rifampin / pharmacology*
Species Specificity
|
IF |
1.566
|
Times Cited |
28
|
WOS Category
|
IMMUNOLOGY
MICROBIOLOGY
|
Resource |
Pathogenic microorganisms |
IFM 0025
IFM 0132
IFM 0147
IFM 0149
IFM 0150
IFM 0161
IFM 0162
IFM 0259
IFM 0359
IFM 0405
IFM 0413
IFM 0414
IFM 0433
IFM 0451
IFM 0452
IFM 0453
IFM 0454
IFM 0473
IFM 0474
IFM 0475
IFM 0476
IFM 0477
IFM 0478
IFM 0479
IFM 2057 |