RRC ID 32235
Author Song ZH, Yu HY, Wang P, Mao GK, Liu WX, Li MN, Wang HN, Shang YL, Liu C, Xu ZL, Sun QY, Li W.
Title Germ cell-specific Atg7 knockout results in primary ovarian insufficiency in female mice.
Journal Cell Death Dis
Abstract Primary ovarian insufficiency (POI) is a common cause of infertility in around 1-2% of women aged <40 years. However, the mechanisms that cause POI are still poorly understood. Here we showed that germ cell-specific knockout of an essential autophagy induction gene Atg7 led to subfertility in female mice. The subfertility of Atg7 deletion females was caused by severe ovarian follicle loss, which is very similar to human POI patients. Further investigation revealed that germ cell-specific Atg7 knockout resulted in germ cell over-loss at the neonatal transition period. In addition, our in vitro studies also demonstrated that autophagy could protect oocytes from over-loss by apoptosis in neonatal ovaries under the starvation condition. Taken together, our results uncover a new role for autophagy in the regulation of ovarian primordial follicle reservation and hint that autophagy-related genes might be potential pathogenic genes to POI of women.
Volume 6(1)
Pages e1589
Published 2015-1-15
DOI 10.1038/cddis.2014.559
PII cddis2014559
PMID 25590799
PMC PMC4669757
MeSH Animals Animals, Newborn Apoptosis Autophagy Autophagy-Related Protein 7 Cell Count Female Fetus / pathology Gene Deletion Humans Infertility, Female / metabolism Infertility, Female / pathology Mice Mice, Knockout Microtubule-Associated Proteins / deficiency* Microtubule-Associated Proteins / metabolism Oocytes / metabolism Oocytes / pathology Organ Specificity Ovarian Follicle / embryology Ovarian Follicle / pathology Ovum / metabolism* Ovum / pathology Primary Ovarian Insufficiency / metabolism* Primary Ovarian Insufficiency / pathology*
IF 6.304
Times Cited 46
Mice RBRC02759