| RRC ID |
32236
|
| Author |
Jeney V, Ramos S, Bergman ML, Bechmann I, Tischer J, Ferreira A, Oliveira-Marques V, Janse CJ, Rebelo S, Cardoso S, Soares MP.
|
| Title |
Control of disease tolerance to malaria by nitric oxide and carbon monoxide.
|
| Journal |
Cell Rep
|
| Abstract |
Nitric oxide (NO) and carbon monoxide (CO) are gasotransmitters that suppress the development of severe forms of malaria associated with Plasmodium infection. Here, we addressed the mechanism underlying their protective effect against experimental cerebral malaria (ECM), a severe form of malaria that develops in Plasmodium-infected mice, which resembles, in many aspects, human cerebral malaria (CM). NO suppresses the pathogenesis of ECM via a mechanism involving (1) the transcription factor nuclear factor erythroid 2-related factor 2 (NRF-2), (2) induction of heme oxygenase-1 (HO-1), and (3) CO production via heme catabolism by HO-1. The protection afforded by NO is associated with inhibition of CD4(+) T helper (TH) and CD8(+) cytotoxic (TC) T cell activation in response to Plasmodium infection via a mechanism involving HO-1 and CO. The protective effect of NO and CO is not associated with modulation of host pathogen load, suggesting that these gasotransmitters establish a crosstalk-conferring disease tolerance to Plasmodium infection.
|
| Volume |
8(1)
|
| Pages |
126-36
|
| Published |
2014-7-10
|
| DOI |
10.1016/j.celrep.2014.05.054
|
| PII |
S2211-1247(14)00448-3
|
| PMID |
24981859
|
| MeSH |
Animals
CD8-Positive T-Lymphocytes / drug effects
CD8-Positive T-Lymphocytes / immunology
Carbon Monoxide / metabolism
Carbon Monoxide / pharmacology*
Carbon Monoxide / therapeutic use
Heme Oxygenase-1 / genetics
Heme Oxygenase-1 / metabolism
Immune Tolerance*
Lymphocyte Activation
Malaria, Cerebral / drug therapy
Malaria, Cerebral / immunology*
Mice
Mice, Inbred C57BL
NF-E2-Related Factor 2 / genetics
NF-E2-Related Factor 2 / metabolism
Nitric Oxide / pharmacology*
Nitric Oxide / therapeutic use
T-Lymphocytes, Cytotoxic / drug effects
T-Lymphocytes, Cytotoxic / immunology
T-Lymphocytes, Helper-Inducer / drug effects
T-Lymphocytes, Helper-Inducer / immunology
|
| IF |
8.109
|
| Times Cited |
39
|
|
WOS Category
|
CELL BIOLOGY
|
| Resource |
| Mice |
RBRC01390 |
