論文 - 詳細
| RRC ID | 32381 |
|---|---|
| 著者 | Schosserer M, Minois N, Angerer TB, Amring M, Dellago H, Harreither E, Calle-Perez A, Pircher A, Gerstl MP, Pfeifenberger S, Brandl C, Sonntagbauer M, Kriegner A, Linder A, Weinhäusel A, Mohr T, Steiger M, Mattanovich D, Rinnerthaler M, Karl T, Sharma S, Entian KD, Kos M, Breitenbach M, Wilson IB, Polacek N, Grillari-Voglauer R, Breitenbach-Koller L, Grillari J. |
| タイトル | Methylation of ribosomal RNA by NSUN5 is a conserved mechanism modulating organismal lifespan. |
| ジャーナル | Nat Commun |
| Abstract |
Several pathways modulating longevity and stress resistance converge on translation by targeting ribosomal proteins or initiation factors, but whether this involves modifications of ribosomal RNA is unclear. Here, we show that reduced levels of the conserved RNA methyltransferase NSUN5 increase the lifespan and stress resistance in yeast, worms and flies. Rcm1, the yeast homologue of NSUN5, methylates C2278 within a conserved region of 25S rRNA. Loss of Rcm1 alters the structural conformation of the ribosome in close proximity to C2278, as well as translational fidelity, and favours recruitment of a distinct subset of oxidative stress-responsive mRNAs into polysomes. Thus, rather than merely being a static molecular machine executing translation, the ribosome exhibits functional diversity by modification of just a single rRNA nucleotide, resulting in an alteration of organismal physiological behaviour, and linking rRNA-mediated translational regulation to modulation of lifespan, and differential stress response. |
| 巻・号 | 6 |
| ページ | 6158 |
| 公開日 | 2015-1-30 |
| DOI | 10.1038/ncomms7158 |
| PII | ncomms7158 |
| PMID | 25635753 |
| PMC | PMC4317494 |
| MeSH | Animals Drosophila Female Hermaphroditic Organisms / genetics Hermaphroditic Organisms / physiology Humans Life Expectancy Male Methylation* Mice RNA, Ribosomal / genetics* RNA, Ribosomal / physiology Saccharomyces cerevisiae / genetics Saccharomyces cerevisiae / physiology |
| IF | 12.121 |
| 引用数 | 89 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 36 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 線虫 | tm3898 |
| ショウジョウバエ | dNsun5 |