Reference - Detail
| RRC ID | 32383 |
|---|---|
| Author | Nelson MD, Lee KH, Churgin MA, Hill AJ, Van Buskirk C, Fang-Yen C, Raizen DM. |
| Title | FMRFamide-like FLP-13 neuropeptides promote quiescence following heat stress in Caenorhabditis elegans. |
| Journal | Curr Biol |
| Abstract |
Among the most important decisions an animal makes is whether to engage in active movement and feeding behavior or to become quiescent. The molecular signaling mechanisms underlying this decision remain largely unknown. The nematode Caenorhabditis elegans displays sleep-like quiescence following exposures that result in cellular stress. The neurosecretory ALA neuron is required for this stress-induced recovery quiescence, but the mechanisms by which ALA induces quiescence have been unknown. We report here that quiescence induced by heat stress requires ALA depolarization and release of FMRFamide-like neuropeptides encoded by the flp-13 gene. Optogenetic activation of ALA reduces feeding and locomotion in a FLP-13-dependent manner. Overexpression of flp-13 is sufficient to induce quiescent behavior during normally active periods. We have here identified a major biological role for FMRFamide-like neuropeptides in nematodes, and we suggest that they may function in a similar capacity in other organisms. |
| Volume | 24(20) |
| Pages | 2406-10 |
| Published | 2014-10-20 |
| DOI | 10.1016/j.cub.2014.08.037 |
| PII | S0960-9822(14)01050-1 |
| PMID | 25264253 |
| PMC | PMC4254296 |
| MeSH | Animals Animals, Genetically Modified Caenorhabditis elegans / metabolism* Caenorhabditis elegans / physiology Caenorhabditis elegans Proteins / metabolism* Caenorhabditis elegans Proteins / physiology Chloride Channels / genetics Chloride Channels / metabolism Drosophila Proteins / genetics Drosophila Proteins / metabolism FMRFamide / analogs & derivatives* FMRFamide / genetics FMRFamide / metabolism Feeding Behavior Gene Expression Regulation Hot Temperature / adverse effects* Locomotion / physiology Stress, Physiological / physiology* |
| IF | 9.601 |
| Times Cited | 56 |
| WOS Category | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 5 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| C.elegans | tm2427 |