Reference - Detail
| RRC ID | 32387 |
|---|---|
| Author | Kim MJ, Choe KM. |
| Title | Basement membrane and cell integrity of self-tissues in maintaining Drosophila immunological tolerance. |
| Journal | PLoS Genet |
| Abstract |
The mechanism underlying immune system recognition of different types of pathogens has been extensively studied over the past few decades; however, the mechanism by which healthy self-tissue evades an attack by its own immune system is less well-understood. Here, we established an autoimmune model of melanotic mass formation in Drosophila by genetically disrupting the basement membrane. We found that the basement membrane endows otherwise susceptible target tissues with self-tolerance that prevents autoimmunity, and further demonstrated that laminin is a key component for both structural maintenance and the self-tolerance checkpoint function of the basement membrane. Moreover, we found that cell integrity, as determined by cell-cell interaction and apicobasal polarity, functions as a second discrete checkpoint. Target tissues became vulnerable to blood cell encapsulation and subsequent melanization only after loss of both the basement membrane and cell integrity. |
| Volume | 10(10) |
| Pages | e1004683 |
| Published | 2014-10-1 |
| DOI | 10.1371/journal.pgen.1004683 |
| PII | PGENETICS-D-14-00776 |
| PMID | 25329560 |
| PMC | PMC4199487 |
| MeSH | Animals Animals, Genetically Modified Autoimmunity / genetics Basement Membrane / cytology* Basement Membrane / immunology Cell Communication Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila melanogaster / cytology Drosophila melanogaster / genetics Drosophila melanogaster / immunology* Immune Tolerance* Laminin / genetics Laminin / metabolism Larva / immunology RNA Interference |
| IF | 5.175 |
| Times Cited | 8 |
| WOS Category | GENETICS & HEREDITY |
| Altmetric score |
オルトメトリクス指標項目
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| The most frequently cited source | X(Twitter) |
| Total number of mentions | 2 |
| Altmetric score changes over past 6months | 0.0 |
| Resource | |
| Drosophila | 16858R-3 12497R-1 12908R-3 1771R-1 16827R-2 1762R-1 1560R-1 8470R-4 11990R-2 1725R-1 5803R-1 |