論文 - 詳細
| RRC ID | 32391 |
|---|---|
| 著者 | Ohhara Y, Shimada-Niwa Y, Niwa R, Kayashima Y, Hayashi Y, Akagi K, Ueda H, Yamakawa-Kobayashi K, Kobayashi S. |
| タイトル | Autocrine regulation of ecdysone synthesis by β3-octopamine receptor in the prothoracic gland is essential for Drosophila metamorphosis. |
| ジャーナル | Proc Natl Acad Sci U S A |
| Abstract |
In Drosophila, pulsed production of the steroid hormone ecdysone plays a pivotal role in developmental transitions such as metamorphosis. Ecdysone production is regulated in the prothoracic gland (PG) by prothoracicotropic hormone (PTTH) and insulin-like peptides (Ilps). Here, we show that monoaminergic autocrine regulation of ecdysone biosynthesis in the PG is essential for metamorphosis. PG-specific knockdown of a monoamine G protein-coupled receptor, β3-octopamine receptor (Octβ3R), resulted in arrested metamorphosis due to lack of ecdysone. Knockdown of tyramine biosynthesis genes expressed in the PG caused similar defects in ecdysone production and metamorphosis. Moreover, PTTH and Ilps signaling were impaired by Octβ3R knockdown in the PG, and activation of these signaling pathways rescued the defect in metamorphosis. Thus, monoaminergic autocrine signaling in the PG regulates ecdysone biogenesis in a coordinated fashion on activation by PTTH and Ilps. We propose that monoaminergic autocrine signaling acts downstream of a body size checkpoint that allows metamorphosis to occur when nutrients are sufficiently abundant. |
| 巻・号 | 112(5) |
| ページ | 1452-7 |
| 公開日 | 2015-2-3 |
| DOI | 10.1073/pnas.1414966112 |
| PII | 1414966112 |
| PMID | 25605909 |
| PMC | PMC4321272 |
| MeSH | Animals Drosophila / growth & development* Ecdysone / biosynthesis* Insect Hormones / metabolism Larva / growth & development Metamorphosis, Biological* Receptors, Biogenic Amine / metabolism Receptors, Biogenic Amine / physiology* Signal Transduction Thorax / physiology* Tyramine / biosynthesis |
| IF | 9.412 |
| 引用数 | 25 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | 31348R-1 10687R-1 |