論文 - 詳細
| RRC ID | 32419 |
|---|---|
| 著者 | Mishra AK, Tsachaki M, Rister J, Ng J, Celik A, Sprecher SG. |
| タイトル | Binary cell fate decisions and fate transformation in the Drosophila larval eye. |
| ジャーナル | PLoS Genet |
| Abstract |
The functionality of sensory neurons is defined by the expression of specific sensory receptor genes. During the development of the Drosophila larval eye, photoreceptor neurons (PRs) make a binary choice to express either the blue-sensitive Rhodopsin 5 (Rh5) or the green-sensitive Rhodopsin 6 (Rh6). Later during metamorphosis, ecdysone signaling induces a cell fate and sensory receptor switch: Rh5-PRs are re-programmed to express Rh6 and become the eyelet, a small group of extraretinal PRs involved in circadian entrainment. However, the genetic and molecular mechanisms of how the binary cell fate decisions are made and switched remain poorly understood. We show that interplay of two transcription factors Senseless (Sens) and Hazy control cell fate decisions, terminal differentiation of the larval eye and its transformation into eyelet. During initial differentiation, a pulse of Sens expression in primary precursors regulates their differentiation into Rh5-PRs and repression of an alternative Rh6-cell fate. Later, during the transformation of the larval eye into the adult eyelet, Sens serves as an anti-apoptotic factor in Rh5-PRs, which helps in promoting survival of Rh5-PRs during metamorphosis and is subsequently required for Rh6 expression. Comparably, during PR differentiation Hazy functions in initiation and maintenance of rhodopsin expression. Hazy represses Sens specifically in the Rh6-PRs, allowing them to die during metamorphosis. Our findings show that the same transcription factors regulate diverse aspects of larval and adult PR development at different stages and in a context-dependent manner. |
| 巻・号 | 9(12) |
| ページ | e1004027 |
| 公開日 | 2013-12-26 |
| DOI | 10.1371/journal.pgen.1004027 |
| PII | PGENETICS-D-13-02831 |
| PMID | 24385925 |
| PMC | PMC3873242 |
| MeSH | Animals Cell Differentiation / genetics Cell Lineage / genetics* Drosophila Proteins / genetics* Drosophila Proteins / metabolism Drosophila melanogaster / genetics Drosophila melanogaster / growth & development Drosophila melanogaster / metabolism Ecdysone / biosynthesis Eye / growth & development* Eye / metabolism Gene Expression Regulation, Developmental Larva / growth & development Larva / metabolism Metamorphosis, Biological / genetics* Nuclear Proteins / genetics* Nuclear Proteins / metabolism Photoreceptor Cells, Invertebrate / cytology Photoreceptor Cells, Invertebrate / metabolism Rhodopsin / genetics Rhodopsin / metabolism Sensory Receptor Cells / cytology Sensory Receptor Cells / metabolism Transcription Factors / genetics* Transcription Factors / metabolism |
| IF | 5.175 |
| 引用数 | 9 |
| WOS 分野 | GENETICS & HEREDITY |
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 4 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
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