RRC ID 32435
Author Schmid MR, Anderl I, Vesala L, Vanha-aho LM, Deng XJ, Rämet M, Hultmark D.
Title Control of Drosophila blood cell activation via Toll signaling in the fat body.
Journal PLoS One
Abstract The Toll signaling pathway, first discovered in Drosophila, has a well-established role in immune responses in insects as well as in mammals. In Drosophila, the Toll-dependent induction of antimicrobial peptide production has been intensely studied as a model for innate immune responses in general. Besides this humoral immune response, Toll signaling is also known to activate blood cells in a reaction that is similar to the cellular immune response to parasite infections, but the mechanisms of this response are poorly understood. Here we have studied this response in detail, and found that Toll signaling in several different tissues can activate a cellular immune defense, and that this response does not require Toll signaling in the blood cells themselves. Like in the humoral immune response, we show that Toll signaling in the fat body (analogous to the liver in vertebrates) is of major importance in the Toll-dependent activation of blood cells. However, this Toll-dependent mechanism of blood cell activation contributes very little to the immune response against the parasitoid wasp, Leptopilina boulardi, probably because the wasp is able to suppress Toll induction. Other redundant pathways may be more important in the defense against this pathogen.
Volume 9(8)
Pages e102568
Published 2014-8-7
DOI 10.1371/journal.pone.0102568
PII PONE-D-14-13634
PMID 25102059
PMC PMC4125153
MeSH Animals Drosophila / immunology* Drosophila / metabolism Drosophila / parasitology Drosophila Proteins / genetics Drosophila Proteins / metabolism Drosophila Proteins / physiology* Fat Body / metabolism* Hemocytes / metabolism* Host-Parasite Interactions / immunology* Immunity, Cellular* Larva / immunology* Larva / metabolism Larva / parasitology Signal Transduction Toll-Like Receptors / genetics Toll-Like Receptors / metabolism Toll-Like Receptors / physiology* Wasps / physiology
IF 2.74
Times Cited 37
Drosophila DGRC#113084