論文 - 詳細
| RRC ID | 32436 |
|---|---|
| 著者 | Schoofs A, Hückesfeld S, Schlegel P, Miroschnikow A, Peters M, Zeymer M, Spieß R, Chiang AS, Pankratz MJ. |
| タイトル | Selection of motor programs for suppressing food intake and inducing locomotion in the Drosophila brain. |
| ジャーナル | PLoS Biol |
| Abstract |
Central mechanisms by which specific motor programs are selected to achieve meaningful behaviors are not well understood. Using electrophysiological recordings from pharyngeal nerves upon central activation of neurotransmitter-expressing cells, we show that distinct neuronal ensembles can regulate different feeding motor programs. In behavioral and electrophysiological experiments, activation of 20 neurons in the brain expressing the neuropeptide hugin, a homolog of mammalian neuromedin U, simultaneously suppressed the motor program for food intake while inducing the motor program for locomotion. Decreasing hugin neuropeptide levels in the neurons by RNAi prevented this action. Reducing the level of hugin neuronal activity alone did not have any effect on feeding or locomotion motor programs. Furthermore, use of promoter-specific constructs that labeled subsets of hugin neurons demonstrated that initiation of locomotion can be separated from modulation of its motor pattern. These results provide insights into a neural mechanism of how opposing motor programs can be selected in order to coordinate feeding and locomotive behaviors. |
| 巻・号 | 12(6) |
| ページ | e1001893 |
| 公開日 | 2014-6-1 |
| DOI | 10.1371/journal.pbio.1001893 |
| PII | PBIOLOGY-D-14-00605 |
| PMID | 24960360 |
| PMC | PMC4068981 |
| MeSH | Animals Central Nervous System / physiology* Feeding Behavior / physiology* Locomotion / physiology* |
| IF | 7.076 |
| 引用数 | 40 |
| WOS 分野 | BIOLOGY BIOCHEMISTRY & MOLECULAR BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 3 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#113901 |