論文 - 詳細
| RRC ID | 32540 |
|---|---|
| 著者 | Mizutani R, Saiga R, Takeuchi A, Uesugi K, Suzuki Y. |
| タイトル | Three-dimensional network of Drosophila brain hemisphere. |
| ジャーナル | J Struct Biol |
| Abstract |
The first step to understanding brain function is to determine the brain's network structure. We report a three-dimensional analysis of the brain network of the fruit fly Drosophila melanogaster by synchrotron-radiation tomographic microscopy. A skeletonized wire model of the left half of the brain network was built by tracing the three-dimensional distribution of X-ray absorption coefficients. The obtained models of neuronal processes were classified into groups on the basis of their three-dimensional structures. These classified groups correspond to neuronal tracts that send long-range projections or repeated structures of the optic lobe. The skeletonized model is also composed of neuronal processes that could not be classified into the groups. The distribution of these unclassified structures correlates with the distribution of contacts between neuronal processes. This suggests that neurons that cannot be classified into typical structures should play important roles in brain functions. The quantitative description of the brain network provides a basis for structural and statistical analyses of the Drosophila brain. The challenge is to establish a methodology for reconstructing the brain network in a higher-resolution image, leading to a comprehensive understanding of the brain structure. |
| 巻・号 | 184(2) |
| ページ | 271-9 |
| 公開日 | 2013-11-1 |
| DOI | 10.1016/j.jsb.2013.08.012 |
| PII | S1047-8477(13)00229-3 |
| PMID | 24012710 |
| MeSH | Animals Brain / diagnostic imaging Brain / ultrastructure Drosophila melanogaster / ultrastructure* Electron Microscope Tomography Imaging, Three-Dimensional Models, Biological Nerve Net / diagnostic imaging Nerve Net / ultrastructure* X-Ray Microtomography |
| IF | 3.071 |
| 引用数 | 13 |
| WOS 分野 | BIOPHYSICS BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 41 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | |