論文 - 詳細
| RRC ID | 32542 |
|---|---|
| 著者 | Plaçais PY, Trannoy S, Friedrich AB, Tanimoto H, Preat T. |
| タイトル | Two pairs of mushroom body efferent neurons are required for appetitive long-term memory retrieval in Drosophila. |
| ジャーナル | Cell Rep |
| Abstract |
One of the challenges facing memory research is to combine network- and cellular-level descriptions of memory encoding. In this context, Drosophila offers the opportunity to decipher, down to single-cell resolution, memory-relevant circuits in connection with the mushroom bodies (MBs), prominent structures for olfactory learning and memory. Although the MB-afferent circuits involved in appetitive learning were recently described, the circuits underlying appetitive memory retrieval remain unknown. We identified two pairs of cholinergic neurons efferent from the MB α vertical lobes, named MB-V3, that are necessary for the retrieval of appetitive long-term memory (LTM). Furthermore, LTM retrieval was correlated to an enhanced response to the rewarded odor in these neurons. Strikingly, though, silencing the MB-V3 neurons did not affect short-term memory (STM) retrieval. This finding supports a scheme of parallel appetitive STM and LTM processing. |
| 巻・号 | 5(3) |
| ページ | 769-80 |
| 公開日 | 2013-11-14 |
| DOI | 10.1016/j.celrep.2013.09.032 |
| PII | S2211-1247(13)00555-X |
| PMID | 24209748 |
| MeSH | Animals Animals, Genetically Modified Appetitive Behavior / physiology* Drosophila / physiology* Female Memory, Long-Term / physiology* Mushroom Bodies / physiology* Neurons, Efferent / physiology* |
| IF | 8.109 |
| 引用数 | 46 |
| WOS 分野 | CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | X(Twitter) |
| 各媒体での言及数の合計 | 1 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | NP7125 (DGRC#114088) |