RRC ID 32542
著者 Plaçais PY, Trannoy S, Friedrich AB, Tanimoto H, Preat T.
タイトル Two pairs of mushroom body efferent neurons are required for appetitive long-term memory retrieval in Drosophila.
ジャーナル Cell Rep
Abstract One of the challenges facing memory research is to combine network- and cellular-level descriptions of memory encoding. In this context, Drosophila offers the opportunity to decipher, down to single-cell resolution, memory-relevant circuits in connection with the mushroom bodies (MBs), prominent structures for olfactory learning and memory. Although the MB-afferent circuits involved in appetitive learning were recently described, the circuits underlying appetitive memory retrieval remain unknown. We identified two pairs of cholinergic neurons efferent from the MB α vertical lobes, named MB-V3, that are necessary for the retrieval of appetitive long-term memory (LTM). Furthermore, LTM retrieval was correlated to an enhanced response to the rewarded odor in these neurons. Strikingly, though, silencing the MB-V3 neurons did not affect short-term memory (STM) retrieval. This finding supports a scheme of parallel appetitive STM and LTM processing.
巻・号 5(3)
ページ 769-80
公開日 2013-11-14
DOI 10.1016/j.celrep.2013.09.032
PII S2211-1247(13)00555-X
PMID 24209748
MeSH Animals Animals, Genetically Modified Appetitive Behavior / physiology* Drosophila / physiology* Female Memory, Long-Term / physiology* Mushroom Bodies / physiology* Neurons, Efferent / physiology*
IF 8.109
引用数 46
WOS 分野 CELL BIOLOGY
リソース情報
ショウジョウバエ NP7125 (DGRC#114088)