論文 - 詳細
| RRC ID | 32544 |
|---|---|
| 著者 | Nelson C, Ambros V, Baehrecke EH. |
| タイトル | miR-14 regulates autophagy during developmental cell death by targeting ip3-kinase 2. |
| ジャーナル | Mol Cell |
| Abstract |
Macroautophagy (autophagy) is a lysosome-dependent degradation process that has been implicated in age-associated diseases. Autophagy is involved in both cell survival and cell death, but little is known about the mechanisms that distinguish its use during these distinct cell fates. Here, we identify the microRNA miR-14 as being both necessary and sufficient for autophagy during developmentally regulated cell death in Drosophila. Loss of miR-14 prevented induction of autophagy during salivary gland cell death, but had no effect on starvation-induced autophagy in the fat body. Moreover, misexpression of miR-14 was sufficient to prematurely induce autophagy in salivary glands, but not in the fat body. Importantly, miR-14 regulates this context-specific autophagy through its target, inositol 1,4,5-trisphosphate kinase 2 (ip3k2), thereby affecting inositol 1,4,5-trisphosphate (IP3) signaling and calcium levels during salivary gland cell death. This study provides in vivo evidence of microRNA regulation of autophagy through modulation of IP3 signaling. |
| 巻・号 | 56(3) |
| ページ | 376-388 |
| 公開日 | 2014-11-6 |
| DOI | 10.1016/j.molcel.2014.09.011 |
| PII | S1097-2765(14)00718-7 |
| PMID | 25306920 |
| PMC | PMC4252298 |
| MeSH | Animals Autophagy* Calcium / metabolism Cell Line Drosophila Proteins / genetics* Drosophila Proteins / metabolism Drosophila melanogaster / cytology* Drosophila melanogaster / enzymology Drosophila melanogaster / growth & development Inositol 1,4,5-Trisphosphate / metabolism Larva / cytology Larva / enzymology Larva / growth & development MicroRNAs / physiology* Phosphotransferases (Alcohol Group Acceptor) / genetics* Phosphotransferases (Alcohol Group Acceptor) / metabolism RNA Interference Salivary Glands / cytology Second Messenger Systems |
| IF | 15.584 |
| 引用数 | 35 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | |
| 各媒体での言及数の合計 | 12 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| ショウジョウバエ | DGRC#123222 |