論文 - 詳細
| RRC ID | 3258 |
|---|---|
| 著者 | Yamamoto K, Ishihama A. |
| タイトル | Transcriptional response of Escherichia coli to external zinc. |
| ジャーナル | J Bacteriol |
| Abstract |
Transcriptional response of Escherichia coli to extracellular zinc was studied using DNA microarray and S1 mapping assays. Addition of external zinc induced the expression of zinc exporter ZntA and inhibited the expression of zinc importer ZnuC. In the continuous presence of zinc, ZnuC repression took place at lower zinc concentrations than ZntA induction. The microarray assay indicated that the addition of excess external zinc induces the expression of many genes that are organized in the regulon for cysteine biosynthesis, implying that cysteine plays a role in transient trapping of free zinc for maintenance of zinc homeostasis. Besides the RpoE regulon, other genes were also induced by zinc, suggesting that periplasmic proteins denatured by zinc induce the genes for protein repair. The microarray data of the newly identified zinc-responsive promoters were confirmed by S1 mapping. |
| 巻・号 | 187(18) |
| ページ | 6333-40 |
| 公開日 | 2005-9-1 |
| DOI | 10.1128/JB.187.18.6333-6340.2005 |
| PII | 187/18/6333 |
| PMID | 16159766 |
| PMC | PMC1236622 |
| MeSH | DNA, Bacterial / genetics Escherichia coli / drug effects* Escherichia coli / genetics Genes, Bacterial Transcription, Genetic / drug effects* Zinc / pharmacology* |
| IF | 3.006 |
| 引用数 | 65 |
| WOS 分野 | MICROBIOLOGY |
| オルトメトリクス指標 |
オルトメトリクス指標項目
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| 最多言及媒体 | Patent(IFI CLAIMS) |
| 各媒体での言及数の合計 | 6 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| 原核生物(大腸菌) | W3110 |