Reference - Detail
|Author||Mikami Y, Yu SF, Yazawa K, Fukushima K, Maeda A, Uno J, Terao K, Saito N, Kubo A, Suzuki K.|
|Title||A toxic substance produced by Nocardia otitidiscaviarum isolated from cutaneous nocardiosis.|
During our studies on toxic substances from clinically isolated Nocarida, a new isolate identified as Nocardia otitidiscaviarum from cutaneous nocardiosis was found to produce a toxic substance called HS-6 that had strong in vitro as well as in vivo toxicity. The mouse intraperitoneal LD50 value was 1.25 mg/kg and the ED50 value for L1210 cultured cells was 0.3 ng/ml. The structure of HS-6 was determined and found to belong to the 16-membered macrocyclic group with a molecular formula of C43H68O12. HS-6 also showed activity against pathogenic fungi such as Cryptococcus neoformans.
|MeSH||Aged Aged, 80 and over Animals Bacterial Toxins / biosynthesis* Bacterial Toxins / chemistry Bacterial Toxins / toxicity Chromatography, Gas Humans Leukemia L1210 Magnetic Resonance Spectroscopy Male Mass Spectrometry Mice Molecular Structure Nocardia / classification Nocardia / metabolism* Nocardia Infections / microbiology* Skin Diseases, Infectious / microbiology* Tumor Cells, Cultured|
|Pathogenic microorganisms||IFM 0273|