論文 - 詳細
| RRC ID | 32609 |
|---|---|
| 著者 | Mikami Y, Yu SF, Yazawa K, Fukushima K, Maeda A, Uno J, Terao K, Saito N, Kubo A, Suzuki K. |
| タイトル | A toxic substance produced by Nocardia otitidiscaviarum isolated from cutaneous nocardiosis. |
| ジャーナル | Mycopathologia |
| Abstract |
During our studies on toxic substances from clinically isolated Nocarida, a new isolate identified as Nocardia otitidiscaviarum from cutaneous nocardiosis was found to produce a toxic substance called HS-6 that had strong in vitro as well as in vivo toxicity. The mouse intraperitoneal LD50 value was 1.25 mg/kg and the ED50 value for L1210 cultured cells was 0.3 ng/ml. The structure of HS-6 was determined and found to belong to the 16-membered macrocyclic group with a molecular formula of C43H68O12. HS-6 also showed activity against pathogenic fungi such as Cryptococcus neoformans. |
| 巻・号 | 112(2) |
| ページ | 113-8 |
| 公開日 | 1990-11-1 |
| DOI | 10.1007/BF00436506 |
| PMID | 2293032 |
| MeSH | Aged Aged, 80 and over Animals Bacterial Toxins / biosynthesis* Bacterial Toxins / chemistry Bacterial Toxins / toxicity Chromatography, Gas Humans Leukemia L1210 Magnetic Resonance Spectroscopy Male Mass Spectrometry Mice Molecular Structure Nocardia / classification Nocardia / metabolism* Nocardia Infections / microbiology* Skin Diseases, Infectious / microbiology* Tumor Cells, Cultured |
| IF | 2.452 |
| 引用数 | 12 |
| WOS 分野 | MYCOLOGY |
| リソース情報 | |
| 病原微生物 | IFM 0273 |