RRC ID 32616
Author Shiraishi A, Nakagaki K, Arai T.
Title Role of cell-mediated immunity in the resistance to experimental sporotrichosis in mice.
Journal Mycopathologia
Abstract Congenitally athymic nude (nu/nu) mice showed higher sensitivity to intratestical infection of Sporothrix schenckii than phenotypically normal littermates (nu/+). Active immunization with viable cells enhanced the resistance to intravenous (i.v.) infection of this fungus in BALB/c mice. Nu/nu mice transferred with immune spleen cells acquired the enhancement of resistance to the infection with S. schenckii, but not ones with normal spleen cells. Pre-treatment of OK-432 (Picibanil), one of the macrophage activating agents, enhanced resistance to i.v. infection of this fungus in BALB/c mice. On the other hand, pretreatment of carrageenan, one of the macrophage inhibitors, impaired the resistance. This fungus was intracellularly killed by peritoneal macrophage from OK-432 treated or immunized mice but not by those from normal mice in vitro. These results suggest that activated macrophage, that was mediated by T cells, play an important role in the resistance to S. schenckii in mice.
Volume 120(1)
Pages 15-21
Published 1992-10
PMID 1480205
MeSH Animals Carrageenan / pharmacology Immunity, Cellular / immunology Immunity, Innate / drug effects Immunity, Innate / immunology Immunotherapy, Adoptive Macrophages / immunology* Male Mice Mice, Inbred BALB C Mice, Nude Picibanil / pharmacology Spleen / immunology Sporothrix / growth & development Sporothrix / immunology* Sporotrichosis / immunology* Vaccination
IF 2.278
Times Cited 18
Pathogenic microorganisms IFM 5906