RRC ID 32625
Author Honda A, Kamei K, Unno H, Hiroshima K, Kuriyama T, Miyaji M.
Title A murine model of zygomycosis by Cunninghamella bertholletiae.
Journal Mycopathologia
Abstract Infections by Cunninghamella bertholletiae have been on the increase in recent years. However, little is known about this fungus and its infection. To clarify the pathogenicity of C. bertholletiae, we made a murine model, and to our knowledge, the first infectious model of this fungus. ICR mice pretreated with cortisone acetate and cyclophosphamide were inoculated intratracheally with 5 x 10(5) spores of C. bertholletiae. About half of the mice died by day 4 and 90% died by day 9. C. bertholletiae was cultured from the lungs, and the pathological analysis disclosed diffuse hyphal growth in the lungs, resulting in necrosis in the later stage. Angioinvasion with alveolar hemorrhage was extremely pronounced from the early stage, and this was the most characteristic feature of this infection. Treatment with amphotericin B showed only minimal improvement of survival, comparable to the poor result of this treatment in actual human cases. In fact, our model has many similarities to the actual human infection by C. bertholletiae, and will be useful for further investigations of this infection.
Volume 144(3)
Pages 141-6
Published 1998-1-1
DOI 10.1023/a:1007095831301
PMID 10531680
MeSH Amphotericin B / therapeutic use Animals Antifungal Agents / therapeutic use Blood Vessels / microbiology Blood Vessels / pathology Cortisone / administration & dosage Cortisone / analogs & derivatives Cunninghamella / pathogenicity* Cyclophosphamide / administration & dosage Disease Models, Animal Humans Immunosuppressive Agents / administration & dosage Lung / blood supply Lung / microbiology Lung / pathology Lung Diseases, Fungal / drug therapy Lung Diseases, Fungal / etiology* Lung Diseases, Fungal / pathology Male Mice Mice, Inbred ICR Mucormycosis / drug therapy Mucormycosis / etiology* Mucormycosis / pathology
IF 2.452
Times Cited 16
Pathogenic microorganisms IFM 46114