RRC ID 32686
著者 Kimura M, Maenishi O, Ito H, Ohkusu K.
タイトル Unique histological characteristics of Scedosporium that could aid in its identification.
ジャーナル Pathol Int
Abstract Scedosporium prolificans has been increasingly recognized as an etiological agent of disseminated mycelial infections in profoundly immunocompromised patients. Reported herein is a case of disseminated S. prolificans infection in a patient undergoing anti-neoplastic chemotherapy for acute myeloid leukemia. Antemortem blood culture yielded S. prolificans, which was confirmed on conventional morphological examination and polymerase chain reaction-based DNA sequencing targeting internally transcribed spacer regions. Histopathology of autopsy specimens indicated fungal infection in the heart, lungs, liver, kidneys, spleen, pancreas and gastrointestinal tract, with the development of hemorrhagic and ischemic necrosis. The infecting fungus had developing septate hyphae and was identified as belonging to the genus Scedosporium, on in situ hybridization of tissue. The combination of haphazardly branching hyphae and lemon-shaped conidia appeared to be the most useful distinguishing features to allow differentiation of this fungus from other filamentous fungi in tissue. Three other unique histopathological characteristics of the fungus were noted: (i) parallel hyphae bridged at right angles to produce letter-H patterns; (ii) intravascular conidiation; and (iii) purple conidia in tissue, though these are usually described as brown in most text books. Precise histopathology, in addition to other techniques such as in situ hybridization, can aid in the identification of etiological fungi.
巻・号 60(2)
ページ 131-6
公開日 2010-2-1
DOI 10.1111/j.1440-1827.2009.02491.x
PII PIN2491
PMID 20398199
MeSH Aged Antineoplastic Combined Chemotherapy Protocols / therapeutic use Female Humans Leukemia, Myeloid, Acute / complications Leukemia, Myeloid, Acute / drug therapy Mycetoma / complications Mycetoma / pathology* Scedosporium*
IF 2.11
引用数 11
WOS 分野 PATHOLOGY
リソース情報
病原微生物 IFM 58277