RRC ID |
32736
|
Author |
Taguchi H, Tanaka R, Miyaji M, Nishimura K, Kanno H, Ishiyama H.
|
Title |
[Studies on the effect of combination of amphotericin B and flucytosine on Candida albicans by flow cytometry].
|
Journal |
Kansenshogaku Zasshi
|
Abstract |
The antifungal effects of amphotericin B (AMPH) and flucytosine (5-FC) on three strains of Candida albicans were studied by flow cytometry (FCM). When the IFM4954 and IFM4949 were treated with AMPH or 5-FC alone, cytograms of cell distribution changed at the concentration of 1/2 MIC, respectively. Next, the effect of combination of AMPH and 5-FC were examined. Cytogram of cell distribution of IFM4954 and IFM4949 changed under the combination of 1/4 MIC of AMPH and 1/4 MIC of 5-FC, namely a synergic effect was observed. In conclusion, FCM is a useful apparatus for analysis of the effect of antifungal agents.
|
Volume |
66(4)
|
Pages |
516-21
|
Published |
1992-4-1
|
DOI |
10.11150/kansenshogakuzasshi1970.66.516
|
PMID |
1624846
|
MeSH |
Amphotericin B / pharmacology*
Candida albicans / drug effects*
Drug Therapy, Combination
Flow Cytometry
Flucytosine / pharmacology*
Methods
|
Resource |
Pathogenic microorganisms |
IFM 4949
IFM 4954
IFM 4956 |