論文 - 詳細
| RRC ID | 33056 |
|---|---|
| 著者 | Mondal BC, Mukherjee T, Mandal L, Evans CJ, Sinenko SA, Martinez-Agosto JA, Banerjee U. |
| タイトル | Interaction between differentiating cell- and niche-derived signals in hematopoietic progenitor maintenance. |
| ジャーナル | Cell |
| Abstract |
Maintenance of a hematopoietic progenitor population requires extensive interaction with cells within a microenvironment or niche. In the Drosophila hematopoietic organ, niche-derived Hedgehog signaling maintains the progenitor population. Here, we show that the hematopoietic progenitors also require a signal mediated by Adenosine deaminase growth factor A (Adgf-A) arising from differentiating cells that regulates extracellular levels of adenosine. The adenosine signal opposes the effects of Hedgehog signaling within the hematopoietic progenitor cells and the magnitude of the adenosine signal is kept in check by the level of Adgf-A secreted from differentiating cells. Our findings reveal signals arising from differentiating cells that are required for maintaining progenitor cell quiescence and that function with the niche-derived signal in maintaining the progenitor state. Similar homeostatic mechanisms are likely to be utilized in other systems that maintain relatively large numbers of progenitors that are not all in direct contact with the cells of the niche. |
| 巻・号 | 147(7) |
| ページ | 1589-600 |
| 公開日 | 2011-12-23 |
| DOI | 10.1016/j.cell.2011.11.041 |
| PII | S0092-8674(11)01435-8 |
| PMID | 22196733 |
| PMC | PMC4403793 |
| MeSH | Animals Drosophila / cytology* Drosophila / embryology Drosophila / metabolism* Drosophila Proteins / metabolism Hedgehog Proteins / metabolism Hematopoiesis Hematopoietic System / metabolism Hemocytes / cytology Lymphoid Tissue / cytology Myeloid Cells / metabolism Signal Transduction* Stem Cell Niche* Stem Cells / metabolism |
| IF | 38.637 |
| 引用数 | 105 |
| WOS 分野 | BIOCHEMISTRY & MOLECULAR BIOLOGY CELL BIOLOGY |
| リソース情報 | |
| ショウジョウバエ | |