| RRC ID |
33060
|
| Author |
Shim J, Mukherjee T, Mondal BC, Liu T, Young GC, Wijewarnasuriya DP, Banerjee U.
|
| Title |
Olfactory control of blood progenitor maintenance.
|
| Journal |
Cell
|
| Abstract |
Drosophila hematopoietic progenitor maintenance involves both near neighbor and systemic interactions. This study shows that olfactory receptor neurons (ORNs) function upstream of a small set of neurosecretory cells that express GABA. Upon olfactory stimulation, GABA from these neurosecretory cells is secreted into the circulating hemolymph and binds to metabotropic GABAB receptors expressed on blood progenitors within the hematopoietic organ, the lymph gland. The resulting GABA signal causes high cytosolic Ca(2+), which is necessary and sufficient for progenitor maintenance. Thus, the activation of an odorant receptor is essential for blood progenitor maintenance, and consequently, larvae raised on minimal odor environments fail to sustain a pool of hematopoietic progenitors. This study links sensory perception and the effects of its deprivation on the integrity of the hematopoietic and innate immune systems in Drosophila. PAPERCLIP:
|
| Volume |
155(5)
|
| Pages |
1141-53
|
| Published |
2013-11-21
|
| DOI |
10.1016/j.cell.2013.10.032
|
| PII |
S0092-8674(13)01350-0
|
| PMID |
24267893
|
| PMC |
PMC3865989
|
| MeSH |
Animals
Drosophila melanogaster / cytology*
Drosophila melanogaster / physiology*
Hemolymph / cytology*
Lymphoid Tissue / cytology
Neurons / metabolism
Olfactory Perception
Olfactory Receptor Neurons / metabolism
Signal Transduction
Stem Cells / cytology*
Stem Cells / metabolism
gamma-Aminobutyric Acid / metabolism
|
| IF |
38.637
|
| Times Cited |
50
|
|
WOS Category
|
BIOCHEMISTRY & MOLECULAR BIOLOGY
CELL BIOLOGY
|
| Resource |
| Drosophila |
|
