論文 - 詳細
| RRC ID | 33105 |
|---|---|
| 著者 | Belobrajdic DP, Jobling SA, Morell MK, Taketa S, Bird AR. |
| タイトル | Wholegrain barley β-glucan fermentation does not improve glucose tolerance in rats fed a high-fat diet. |
| ジャーナル | Nutr Res |
| Abstract |
Fermentation of oat and barley β-glucans is believed to mediate in part their metabolic health benefits, but the exact mechanisms remain unclear. In this study, we sought to test the hypothesis that barley β-glucan fermentation raises circulating incretin hormone levels and improves glucose control, independent of other grain components. Male Sprague-Dawley rats (n = 30) were fed a high-fat diet for 6 weeks and then randomly allocated to 1 of 3 dietary treatments for 2 weeks. The low- (LBG, 0% β-glucan) and high- (HBG, 3% β-glucan) β-glucan diets contained 25% wholegrain barley and similar levels of insoluble dietary fiber, available carbohydrate, and energy. A low-fiber diet (basal) was included for comparison. Immediately prior to the dietary intervention, gastric emptying rate (using the (13)C-octanoic breath test) and postprandial glycemic response of each diet were determined. At the end of the study, circulating gut hormone levels were determined; and a glucose tolerance test was performed. The rats were then killed, and indices of cecal fermentation were assessed. Diet did not affect live weight; however, the HBG diet, compared to basal and LBG, reduced food intake, tended to slow gastric emptying, increased cecal digesta mass and individual and total short-chain fatty acid pools, and lowered digesta pH. In contrast, circulating levels of glucose, insulin, gastric-inhibitory peptide, and glucagon-like peptide-1, and glucose tolerance were unaffected by diet. In conclusion, wholegrain barley β-glucan suppressed feed intake and increased cecal fermentation but did not improve postprandial glucose control or insulin sensitivity. |
| 巻・号 | 35(2) |
| ページ | 162-8 |
| 公開日 | 2015-2-1 |
| DOI | 10.1016/j.nutres.2014.12.006 |
| PII | S0271-5317(14)00285-1 |
| PMID | 25622537 |
| MeSH | Animals Blood Glucose Cecum / microbiology* Diet, High-Fat / adverse effects* Dietary Fiber / administration & dosage Eating / drug effects* Fermentation / drug effects* Gastric Inhibitory Polypeptide / metabolism Glucagon-Like Peptide 1 / metabolism Glucose Tolerance Test Hordeum / chemistry* Insulin / blood Male Rats Rats, Sprague-Dawley beta-Glucans / administration & dosage beta-Glucans / pharmacology* |
| IF | 2.767 |
| 引用数 | 15 |
| WOS 分野 | NUTRITION & DIETETICS |
| オルトメトリクス指標 |
オルトメトリクス指標項目
|
| 各媒体での言及数の合計 | 0 |
| 過去6か月間でのオルトメトリクス指標の変動値 | 0.0 |
| リソース情報 | |
| オオムギ | barley low beta glucan mutant |