論文 - 詳細
| RRC ID | 33146 |
|---|---|
| 著者 | Uchida R, Hanaki H, Matsui H, Hamamoto H, Sekimizu K, Iwatsuki M, Kim YP, Tomoda H. |
| タイトル | In vitro and in vivo anti-MRSA activities of nosokomycins. |
| ジャーナル | Drug Discov Ther |
| Abstract |
The anti-methicillin-resistant Staphylococcus aureus (MRSA) activity of nosokomycins A to D discovered in the silkworm-MRSA infection screening was investigated. The minimum inhibitory concentration (MIC) values of nosokomycins for authentic MRSA and S. aureus strains were calculated to be 0.06 to 2.0 μg/mL. They also showed potent inhibitory activity against 54 clinically isolated MRSA strains. Furthermore, nosokomycin A proved effective in the mouse-MRSA infection model. |
| 巻・号 | 8(6) |
| ページ | 249-54 |
| 公開日 | 2014-12-1 |
| DOI | 10.5582/ddt.2014.01050 |
| PMID | 25639304 |
| MeSH | Animals Anti-Bacterial Agents / pharmacology* Bacteria / drug effects Bombyx Dose-Response Relationship, Drug Humans Larva Methicillin-Resistant Staphylococcus aureus / drug effects* Mice Microbial Sensitivity Tests Streptococcal Infections / microbiology Streptomyces / chemistry Vancomycin / therapeutic use |
| 引用数 | 12 |
| リソース情報 | |
| カイコ | |